Results 131 to 140 of about 3,539,790 (303)

Multi-omics approach to understanding dairy cow subfertility

, 2020
Dairy cow subfertility is a worldwide issue arising from multiple factors. One of its main manifestations is up to 40-50% early pregnancy loss in high-milk producing herds, especially when cows are bred early post-partum.
Nicolas Aranciaga (15397298), Charles Hefer (3312360), James Morton (755304), Alastair Ross (3399848), Jessica Gathercole (15395231), Debbie Berg (15396443)   +5 more
core  

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Multi-omic studies on the pathogenesis of Sepsis

Journal of Translational Medicine
Sepsis is a life-threatening inflammatory condition, and its underlying genetic mechanisms are not yet fully elucidated. We applied methods such as Mendelian randomization (MR), genetic correlation analysis, and colocalization analysis to integrate multi-omics data and explore the relationship between genetically associated genes and sepsis, as well as
Hongjie Tong, Yuhang Zhao, Ying Cui, Jiali Yao, Tianlong Zhang   +4 more
openaire   +3 more sources

A spatial transcriptomics comparison of the adult versus metamorphosed axolotl brain

Scientific Data
The Mexican axolotl (Ambystoma mexicanum) is an established model for studying tetrapod regeneration and development. Notably, axolotls exhibit remarkable brain regeneration as adults, a trait rarely observed in other adult vertebrates.
Shuai Wang, Sulei Fu, Xiawei Liu, Yan-Yun Zeng, Lianrui Zhang, Nannan Zhang, Xi Dai, Hanbo Li, Ying Gu, Xiaoyu Wei, Ji-Feng Fei, Yang Liu   +11 more
doaj   +1 more source

Decoding Kidney Pathophysiology: Omics-Driven Approaches in Precision Medicine

Chronic kidney disease (CKD) is a major worldwide health concern because of its progressive nature and complex biology. Traditional diagnostic and therapeutic approaches usually fail to account for disease heterogeneity, resulting in low efficacy ...
Delrue, Charlotte, Marijn M. Speeckaert, Charlotte Delrue, Speeckaert, Marijn   +3 more
core   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Cardiotoxicity of Chemotherapy: A Multi-OMIC Perspective

Journal of Xenobiotics
Chemotherapy-induced cardiotoxicity is a critical issue in cardio-oncology, as cancer treatments often lead to severe cardiovascular complications. Approximately 10% of cancer patients succumb to cardiovascular problems, with lung cancer patients frequently experiencing arrhythmias, cardiac failure, tamponade, and cardiac metastasis.
Yan Ma, Mandy O. J. Grootaert, Raj N. Sewduth   +2 more
openaire   +3 more sources

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

HemAtlas: A Multi-omics Hematopoiesis Database

Genomics, Proteomics & Bioinformatics
Abstract Advancements in high-throughput omics technologies have facilitated a systematic exploration of crucial hematopoietic organs across diverse species. A thorough understanding of hematopoiesis in vivo and facilitation of generating functional hematopoietic stem and progenitor cells (HSPCs) in vitro necessitate a comprehensive ...
Zhixin Kang, Tongtong Zhu, Dong Zou, Mengyao Liu, Yifan Zhang, Lu Wang, Zhang Zhang, Feng Liu   +7 more
openaire   +4 more sources

Chromatin modifiers in human disease: from functional roles to regulatory mechanisms

Molecular Biomedicine
The field of transcriptional regulation has revealed the vital role of chromatin modifiers in human diseases from the beginning of functional exploration to the process of participating in many types of disease regulatory mechanisms.
Yali Nie, Chao Song, Hong Huang, Shuqing Mao, Kai Ding, Huifang Tang   +5 more
doaj   +1 more source