Results 111 to 120 of about 3,539,790 (303)

Spatial multi-omics: deciphering technological landscape of integration of multi-omics and its applications

Journal of Hematology & Oncology
The emergence of spatial multi-omics has helped address the limitations of single-cell sequencing, which often leads to the loss of spatial context among cell populations. Integrated analysis of the genome, transcriptome, proteome, metabolome, and epigenome has enhanced our understanding of cell biology and the molecular basis of human diseases ...
Xiaojie Liu, Ting Peng, Miaochun Xu, Shitong Lin, Bai Hu, Tian Chu, Binghan Liu, Yashi Xu, Wencheng Ding, Li Li, Canhui Cao, Peng Wu   +11 more
openaire   +3 more sources

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source

Dissecting the genetic admixture and forensic signatures of ethnolinguistically diverse Chinese populations via a 114-plex NGS InDel panel

BMC Genomics
Comprehensive characterizations of genetic diversity and demographic models of ethnolinguistically diverse Chinese populations are essential for elucidating their forensic characteristics and evolutionary past.
Chengliang Yang, Changhui Liu, Miaoqiang Lun, Xiaohui Chen, Quyi Xu, Xueyuan Liu, Meiyun He, Linying Ye, Guanglin He, Mengge Wang, Chao Liu   +10 more
doaj   +1 more source

Methods for Integrating Multi-omics Data: Mathematical Aspects.

, 2014
Recently, there has been a growing interest in methods that involve integrated analysis of multi-omics data. Deducing a valuable biological or medical meaning from a multi-omics dataset is a non-trivial problem and, thus, the integrated analysis of these
Ettore Mosca, Gastone Castellani, Luciano Milanesi, Matteo Bersanelli   +3 more
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Important multi-omics pathways identified by PathIntegrate Multi-View on COPDgene multi-omics data.

Important multi-omics pathways identified by PathIntegrate Multi-View on COPDgene multi-omics data.
Cecilia Wieder (11402540), Juliette Cooke (11402543), Timothy Ebbels (2247136), Russell Bowler (3471647), Fabien Jourdan (216798), Rachel PJ Lai (8281866), Clement Frainay (18251699), Nathalie Poupin (195134), Katerina J. Kechris (9921356)   +8 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Systems biology and multi-omics integration: viewpoints from the metabolomics research community

, 2019
The use of multiple omics techniques (i.e., genomics, transcriptomics, proteomics, and metabolomics) is becoming increasingly popular in all facets of life science.
Schirra, Horst J, Horst J. Schirra, Swarup, Sanjay, Schirra, Horst J., Wishart, David, Farhana R. Pinu, David J. Beale, David Wishart, Amy M. Paten, Kouremenos, Konstantinos, Horst J. Schirra, Paten, Amy M, Beale, David J., Paten, Amy M., Pinu, Farhana R, Sanjay Swarup, Konstantinos Kouremenos, David J. Beale, Beale, David J, Farhana R. Pinu, Pinu, Farhana R., Amy M. Paten   +21 more
core   +1 more source