Results 91 to 100 of about 3,539,790 (303)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Forensic utilization of NGS-STRs and evaluation of system efficacy for different kinship identifications

Human Genomics
Background The accurate identification of complex kinship relationships remains a significant challenge in forensic practice. Traditional kinship identification methods, which primarily rely on length polymorphisms of short tandem repeats (STRs), often ...
Hui Xu, Hongbing Yao, Xi Yuan, Qiong Lan, Yifeng Lin, Xiaolian Wu, Qinglin Liang, Qinglin Liu, Lisiteng Luo, Bofeng Zhu   +9 more
doaj   +1 more source

An overview of single-cell omics, spatial omics, and omics integration in axon regeneration

Toward a systems approach for studying axon regeneration, the extractive omics must be integrated with single cell and spatial omics. Although a comprehensive analytical framework exists for single-cell transcriptomics, single-cell proteomics, lipidomics,
Coronado, Michael, Singal, Avani, Bhattacharya, Sanjoy K., Neag, Emily, Bhattacharya, Nivedita, Almobayed, Amr, Gandikota, Nikhil, Akurati, Sneha, Kishor, Krishna S.   +8 more
core   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Harnessing AI-driven approaches for detecting metabolic dysfunction-associated steatotic liver disease, assessing fibrosis, and stratifying hepatocellular carcinoma risk: a scoping review

Frontiers in Oncology
IntroductionNon-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disorder worldwide and a major risk factor for hepatocellular carcinoma (HCC). Its rising prevalence and progression to HCC present major clinical and public health
Anvitha Nagaraj Sharma, Hima Bhagavatula, Michael T. Mapundu, Emile R. Chimusa, Emile R. Chimusa   +4 more
doaj   +1 more source

Plant-pathogen interactions:Making the case for multi-omics analysis of complex pathosystems [PDF]

Understanding plant-pathogen interactions requires a systems-level perspective that single-omics approaches, such as genomics, transcriptomics, proteomics, or metabolomics alone, often fail to provide.
Balotf, Sadegh, Wilson, Richard, Mur, Luis A. J.; id_orcid, Mur, Luis A. J., Hemmati, Roghayeh, Eshaghi, Mahsa, Wilson, Calum   +6 more
core   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Fasting Metabolite Panel for OGTT-Free Diagnosis of Gestational Diabetes Mellitus: A Machine Learning Approach Validated in Dual Cohorts

Diabetes, Metabolic Syndrome and Obesity
Binbin Yin,1,* Yiyun Shen,1,* Qianwen Zhang,2,* Rongchang Chen,2,* Xue Zhang,2 Ziqing Kong,2,3 Yuning Zhu1,4– 6 1Department of Laboratory Medicine, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou ...
Yin B, Shen Y, Zhang Q, Chen R, Zhang X, Kong Z, Zhu Y   +6 more
doaj  

Chromosome-scale genomes of wild and cultivated Morinda officinalis

Scientific Data
Morinda officinalis is a renowned medicinal and edible plant native to southern China and northern Vietnam. Its dried roots, known as bajitian are extensively used in traditional Chinese medicine to treat various ailments. Driven by the increasing market
Ruirui Li, Xiaodie Geng, Min Liu, Guangming Liu, Tong Wei, Huan Liu, Yanqun Li, Sunil Kumar Sahu, Hong Wu   +8 more
doaj   +1 more source

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source