Results 121 to 130 of about 3,539,790 (303)

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Multi‐Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs

Advanced Science
Variations in both transcription and translation of genes play a pivotal role in shaping complex traits and disease phenotypes. However, systematic analyses of genetic variants regulating transcription and translation, as well as their contribution to ...
Chao Wang, Yuanyuan Zhang, Choulin Chen, Xiaoxian Xu, Shenghua Qin, Junyan Qi, Yongzhou Bao, Huiming Li, Ruipu Chen, Weigang Zheng, Zhilong Chen, Lingzhao Fang, Yunxiang Zhao, Yuwen Liu   +13 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Genomic diversity in Chinese Holstein cattle and genome-wide association study for body conformation traits

BMC Genomics
Background The genomic diversity of Chinese Holstein cattle remains insufficiently characterized, and the identification of genes associated with body conformation traits is still limited.
Jinpeng Wang, Yaran Zhang, Chunhong Yang, Zhihua Ju, Yao Xiao, Qiang Jiang, Wenhao Liu, Xiuge Wang, Xiaochao Wei, Yaping Gao, Xiuxin Zhao, Lingling Wang, Yundong Gao, Jianbin Li, Jinming Huang   +14 more
doaj   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Functional profiling of stage-specific proteome and translational transition across human pre-implantation embryo development at a single-cell resolution

Cell Discovery, 2023
Yujiao Dang, Liu Zhu, Peng Yuan, Qiang Liu, Qianying Guo, Xi Chen, Shuaixin Gao, Xiao Liu, Shushen Ji, Yifeng Yuan, Ying Lian, Rong Li, Liying Yan, Catherine C. L. Wong, Jie Qiao   +14 more
doaj   +1 more source

m6A-modified exosome-derived circHIF1α binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia

Journal of Nanobiotechnology
Background Animal and human health are seriously threatened by bacterial infections, which can lead to bacteremia and extremely high rates of morbidity and mortality. Recently, there have been reports indicating the involvement of exosomal circular RNAs (
Jiang Yu, Yidan Gao, Fei Liu, Yuyu Zhang, Jianda Li, Luogang Ding, Sufang Ren, Jie Yang, Jian Jiao, Gong Feng, Zhi Chen, Wenbo Sun, Jiaqiang Wu   +12 more
doaj   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Lysophosphatidic acid drives to mirror-image pain via corpus callosum-mediated propagation of inflammatory responses

Communications Biology
Pain transmission is considered a unilateral process; however, development of bilateral hyperalgesia, including mirror-image pain (MIP), challenges this notion. The neural basis underlying bilateral hyperalgesia remains unclear.
Hiroyuki Neyama, Ryoma Kizu, Rae Maeda, Hiroshi Ueda, Yuki Sugiura   +4 more
doaj   +1 more source

Changes in the microbial community of semen exposed to different simulated forensic situations

Microbiology Spectrum
Semen is one of the common body fluids in sexual crime cases. The current methods of semen identification have certain limitations, so it is necessary to search for other methods.
Yangyang Zheng, Linying Ye, Jieyu Du, Litao Huang, Miaoqiang Lun, Meiyun He, Guichao Xiao, Weian Du, Chao Liu, Ling Chen   +9 more
doaj   +1 more source