Results 221 to 230 of about 79,155 (276)

Multi-Omics Integration Identifies <i>TNFRSF1A</i> as a Causal Mediator of Immune Microenvironment Reprogramming in Diabetic Kidney Disease. [PDF]

Int J Mol Sci
Xie W, Zhao D, Franz H, Schmitt A, Walz G, Yakulov TA.   +5 more
europepmc   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

eQTL and multi-omics integration reveal PPIH as a prognostic and immunotherapeutic biomarker. [PDF]

Front Immunol
Lv F, Zhang X, Wu Y, Li Z, Zheng X, Zhou H, Wang W.   +6 more
europepmc   +1 more source

Time‐Efficient and Informatic‐Skill‐Light Gap‐Filling for Telomere‐to‐Telomere Genome Assembly

Advanced Science, EarlyView.
The paper introduces a novel auxiliary software toolbox GapSuite, consisting of two tools Gap‐Aid and Gap‐Graph, which guides users to fill gaps in chromosome‐level genome assembly using sequence‐extension‐based and assembly‐graph‐based strategies. The two tools enable users with limited informatics expertise to efficiently complete gap‐filling on ...
Dong Xu, Xianjia Zhao, Lianguang Shang, Shaolong Tian, Yanchun Li, Huaming Wen, Qiang Xu, Dongxi Li, Weihua Pan   +8 more
wiley   +1 more source

Multi-Omics Integration Identifies FGF1 as a Diagnostic Biomarker and RAS-MAPK-Driven Pathogenic Factor in Osteoarthritis. [PDF]

J Inflamm Res
Yan Y, Wang C, Zhang M, Jiang X, Cheng W.   +4 more
europepmc   +1 more source

Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D

Advanced Science, EarlyView.
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley   +1 more source

Multi-omics integration reveals functional signatures of gut microbiome in atherosclerosis. [PDF]

Gut Microbes
Shi H, Wu M, Wu X, Liu Z, Jiang S, Li G, Yang Y, Fu Y, Wang Q, Zhang G, Cheng L.   +10 more
europepmc   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

Stress-Induced Plant Specialized Metabolism: Signaling, Multi-Omics Integration, and Plant-Derived Antimicrobial Metabolites to Combat Antimicrobial Resistance. [PDF]

Plants (Basel)
Pérez-Sánchez LE, Ayala-Guerrero LM, Mendieta-Moctezuma A, Villalobos-López MA, Ríos-Meléndez S.   +4 more
europepmc   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source