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Omix: A Multi-Omics Integration Pipeline
2023AbstractSummaryTheOmixpipeline offers an integration and analysis framework for multiomics intended to preprocess, analyse, and visualise multimodal data flexibly to address various research questions. From biomarker discovery and patient stratification to the investigation of complex biological processes,Omixempowers researchers to derive valuable ...
Eléonore Schneegans +5 more
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Integrative Multi-Omics Through Bioinformatics
2018This chapter introduces different aspects of bioinformatics with a brief discussion in the systems biology context. Example applications in network pharmacology of traditional Chinese medicine, systems metabolic engineering, and plant genome-scale modelling are described.
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A multi-omics integrative network map of maize
Nature Genetics, 2022Networks are powerful tools to uncover functional roles of genes in phenotypic variation at a system-wide scale. Here, we constructed a maize network map that contains the genomic, transcriptomic, translatomic and proteomic networks across maize development.
Linqian Han +34 more
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Integration of Multi-Omics Data
Integrating multi-omics data, such as proteomics, metabolomics, and genomes, in precision health provides revolutionary insights into biological systems and individualized treatment plans. This chapter focuses on AI-powered techniques for merging multi-omics data, made possible by high-throughput instruments such as next-generation sequencing and mass ...S. Savitha +5 more
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Integrated multi-omics profiling of nonfunctioning pituitary adenomas
Pituitary, 2020Genetic and epigenetic alterations are involved in pituitary adenoma pathogenesis, however the molecular basis of proliferative nonfunctioning pituitary adenomas (NFPAs) remains unclear. Here, we analyzed integrated multi-omics profiling including copy number variation (CNV), DNA methylation and gene expression of 8 NFPAs.We collected 4 highly ...
Zhenqing Wei +6 more
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Spatial Integration of Multi-Omics Data using the novel Multi-Omics Imaging Integration Toolset
AbstractTo truly understand the cancer biology of heterogenous tumors in the context of precision medicine, it is crucial to use analytical methodology capable of capturing the complexities of multiple omics levels, as well as the spatial heterogeneity of cancer tissue. Different molecular imaging techniques, such as mass spectrometry imaging (MSI) andWess, Maximillian +8 more
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Integrative Multi-Omics for Precision Pulmonology
Precision pulmonology is the revolution inside the field of respiratory medicine by means of transferring schedules to molecular levels. The current chapter shows how an integrative multi-omics approach of combining genomics, transcriptomics, proteomics, metabolomics and microbiomics has the potential to increase the precision of diagnosis and choice ...Soumi Ghosh, Ritik Raj
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