Results 41 to 50 of about 134,499 (265)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Multi-Physics Adaptive Time Step Coupling Algorithm for Light-Water Reactor Core Transient and Accident Simulation

Energies, 2020
A new reactor core multi-physics system addresses the pellet-to-cladding heat transfer modeling to improve full-core operational transient and accident simulation used for assessment of reactor core nuclear safety.
Alexey Cherezov, Jinsu Park, Hanjoo Kim, Jiwon Choe, Deokjung Lee   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Evolutions of induced electromagnetic signatures of submarine under natural cavitation

Zhongguo Jianchuan Yanjiu, 2023
ObjectiveThe induced electromagnetic properties brought forth by disturbed seawater cutting the geomagnetic field can provide important information for non-acoustic detection technologies.
E PENG, Shengnan ZOU, Shizhu LI, Linying LIU   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Recent Advances in Regulation Strategy and Catalytic Mechanism of Bi-Based Catalysts for CO2 Reduction Reaction

Nano-Micro Letters
Highlights Six major types of structural regulation strategies of various Bi-based catalysts used in photoelectrocatalytic CO2 reduction reaction (CO2RR) in recent years are comprehensively summarized.
Jianglong Liu, Yunpeng Liu, Shunzheng Zhao, Baotong Chen, Guang Mo, Zhongjun Chen, Yuechang Wei, Zhonghua Wu   +7 more
doaj   +1 more source

Recent developments and discoveries in natural hazards mitigation research at the NHERI Lehigh Experimental Facility

Frontiers in Built Environment
Natural hazards, including hurricanes and earthquakes, can escalate into catastrophic societal events due to the destruction of the built environment. To minimize the impact of such hazards on vulnerable communities, civil infrastructure must be designed
Liang Cao, Thomas M. Marullo, James Michael Ricles, James Michael Ricles, Richard Sause, Richard Sause, Claudia Reis, Claudia Reis, Joseph Saunders   +8 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Multi-Physics and Multi-Objective Design of an Axial Flux Permanent Magnet-Assisted Synchronous Reluctance Motor for Use in Electric Vehicles

Machines
In this study, an axial flux double airgap permanent magnet-assisted synchronous reluctance motor (AF-Pma-SynRM) was designed for electric vehicles (EVs).
Emre Gözüaçık, Mehmet Akar
doaj   +1 more source