Results 51 to 60 of about 134,499 (265)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Characterization and benchmarking of complete 4D transverse phase space for high-intensity ion beams using novel virtual pepper-pot technique

Scientific Reports
Precise and fast measurement of transverse beam properties is essential for understanding and optimizing particle beams. In this study, a multi-diagnostic approach is employed for high-dimensional transverse phase space reconstruction of high-intensity ...
Emre Cosgun, SeokHo Moon, DongHwan Kim, SeungHyun Lee, HanSung Kim, HyeokJung Kwon, Moses Chung   +6 more
doaj   +1 more source

Data-driven acceleration of multi-physics simulations

Machine Learning: Science and Technology
Abstract Multi-physics simulations play a crucial role in understanding complex systems. However, their computational demands are often prohibitive due to high dimensionality and complex interactions, such that actual calculations often rely on approximations.
Stefan Meinecke, Malte Selig, Felix Köster, Andreas Knorr, Kathy Lüdge   +4 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Smart-substrate: a novel structural design to avert residual stress accretion in directed energy deposition additive manufacturing

Virtual and Physical Prototyping, 2023
Residual stresses, related distortions and cracks are detrimental in metallic Additive Manufacturing (AM). Previously developed stress-control strategies based on reducing thermal gradients hardly diminish the stress concentrations at the built basement ...
Xufei Lu, Guohao Zhang, Michele Chiumenti, Miguel Cervera, Mehdi Slimani, Liang Ma, Lei Wei, Xin Lin   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Manipulating He diffusion in RAFM steels through preintroduced defect engineering under low-energy plasma irradiation

Nuclear Fusion
This study investigates the impact of preintroduced defects on helium (He) diffusion in reduction-activated ferrite/martensitic steel under He plasma irradiation of 100 eV at room temperature.
Jiaqi Li, Xiuxuan Duan, Weiping Zhang, Yi Xiong, Xingxing Zhang, Meidie Wu, Bingsheng Li, Dongliang Chen, Shuoxue Jin   +8 more
doaj   +1 more source

Distributed Workflows for Multi-physics Applications in Aeronautics [PDF]

2008 12th International Conference on Computer Supported Cooperative Work in Design, 2008
The industry requires innovative technologies to support the numeric design and simulation of manufactured products in order to reduce time to market delays and improve the performance of the products and the efficiency of the industries in the global competitive market. Innovation also requires advanced tools to support the design of new products. For
Nguyen, Toan, Desideri, Jean-Antoine, Périaux, Jacques   +2 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Multilevel Parallelism Support for Multi-Physics Coupling

Procedia Computer Science, 2011
AbstractA new challenge in scientific computing is to merge existing simulation models to create new higher fidelity combined (often multi-level) models. While this challenge has been a driving force in climate modeling for nearly a decade, fusion energy and space weather modeling are starting just now to integrate different sub-physics into a single ...
Fang Liu 0028, Masha Sosonkina
openaire   +1 more source