Results 91 to 100 of about 992,003 (291)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Linear second-order problems with Sturm-Liouville-type multi-point boundary conditions

Electronic Journal of Differential Equations, 2012
We consider the eigenvalue problem for the equation $-u'' = lambda u$ on $(-1,1)$, together with general Sturm-Liouville-type, multi-point boundary conditions at $pm 1$. We show that the basic spectral properties of this problem are similar to those
Bryan P. Rynne
doaj  

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

On Caputo–Riemann–Liouville Type Fractional Integro-Differential Equations with Multi-Point Sub-Strip Boundary Conditions

Mathematics, 2020
In this paper, we derive existence and uniqueness results for a nonlinear Caputo–Riemann–Liouville type fractional integro-differential boundary value problem with multi-point sub-strip boundary conditions, via Banach and Krasnosel’skii⏝’s fixed point ...
Ahmed Alsaedi, Amjad F. Albideewi, Sotiris K. Ntouyas, Bashir Ahmad   +3 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Solutions to second order non-homogeneous multi-point BVPs using a fixed-point theorem

Electronic Journal of Differential Equations, 2008
In this article, we study five non-homogeneous multi-point boundary-value problems (BVPs) of second order differential equations with the one-dimensional p-Laplacian.
Yuji Liu
doaj  

Open Spin Chains and Complexity in the High Energy Limit

, 2018
In the high energy limit of scattering amplitudes in Quantum Chromodynamics and supersymmetric theories the dominant Feynman diagrams are characterized by a hidden integrability. A well-known example is that of Odderon exchange, which can be described as
Chachamis, Grigorios, Vera, Agustin Sabio   +1 more
core   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Existence and stability of solutions for a nonlocal multi-point and multi-strip coupled boundary value problem of nonlinear fractional Langevin equations

Bulletin of Mathematical Sciences
In this paper, we investigate a nonlocal multi-point and multi-strip coupled boundary value problem of nonlinear fractional Langevin equations. The standard fixed point theorems (Leray–Schauder’s alternative and Banach’s fixed point theorem) are applied ...
Ahmed Alsaedi, Hafed A. Saeed, Hamed Alsulami   +2 more
doaj   +1 more source

Nonlocal boundary value problems for Hilfer-type pantograph fractional differential equations and inclusions

Advances in Difference Equations, 2020
In this paper, we study boundary value problems, involving the Hilfer fractional derivative, for pantograph fractional differential equations and inclusions supplemented by nonlocal integral boundary conditions.
Athasit Wongcharoen, Sotiris K. Ntouyas, Jessada Tariboon   +2 more
doaj   +1 more source