Results 71 to 80 of about 15,176,596 (284)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Solutions to second order non-homogeneous multi-point BVPs using a fixed-point theorem

Electronic Journal of Differential Equations, 2008
In this article, we study five non-homogeneous multi-point boundary-value problems (BVPs) of second order differential equations with the one-dimensional p-Laplacian.
Yuji Liu
doaj  

Existence and stability of solutions for a nonlocal multi-point and multi-strip coupled boundary value problem of nonlinear fractional Langevin equations

Bulletin of Mathematical Sciences
In this paper, we investigate a nonlocal multi-point and multi-strip coupled boundary value problem of nonlinear fractional Langevin equations. The standard fixed point theorems (Leray–Schauder’s alternative and Banach’s fixed point theorem) are applied ...
Ahmed Alsaedi, Hafed A. Saeed, Hamed Alsulami   +2 more
doaj   +1 more source

Some results on impulsive boundary value problem for fractional differential inclusions

Electronic Journal of Qualitative Theory of Differential Equations, 2011
This paper deals with impulsive fractional differential inclusions with a fractional order multi-point boundary condition and with fractional order impulses.
Jianxin Cao, Haibo Chen
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Positive solutions for singular systems of higher-order multi-point boundary value problems

Mathematical Modelling and Analysis, 2013
We investigate the existence of positive solutions for systems of singular nonlinear higher-order differential equations subject to multi-point boundary conditions.
Johnny Henderson, Rodica Luca
doaj   +1 more source

Nonlocal boundary value problems for Hilfer-type pantograph fractional differential equations and inclusions

Advances in Difference Equations, 2020
In this paper, we study boundary value problems, involving the Hilfer fractional derivative, for pantograph fractional differential equations and inclusions supplemented by nonlocal integral boundary conditions.
Athasit Wongcharoen, Sotiris K. Ntouyas, Jessada Tariboon   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Non-homogeneous boundary-value problems of higher order differential equations with p-Laplacian

Electronic Journal of Differential Equations, 2008
We establish sufficient conditions for the existence of positive solutions to five multi-point boundary value problems. These problems have a common equation (in different function domains) and different boundary conditions.
Yuji Liu
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source