Results 61 to 70 of about 15,176,596 (284)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Linear second-order problems with Sturm-Liouville-type multi-point boundary conditions

Electronic Journal of Differential Equations, 2012
We consider the eigenvalue problem for the equation $-u'' = lambda u$ on $(-1,1)$, together with general Sturm-Liouville-type, multi-point boundary conditions at $pm 1$. We show that the basic spectral properties of this problem are similar to those
Bryan P. Rynne
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Solutions of a multi-point boundary value problem for higher-order differential equations at resonance. (II) [PDF]

, 2005
summary:In this paper, we are concerned with the existence of solutions of the following multi-point boundary value problem consisting of the higher-order differential equation \[ x^{(n)}(t)=f(t,x(t),x^{\prime }(t),\dots ,x^{(n-1)}(t))+e(t)\,,\quad ...
Liu, Yuji, Ge, Weigao
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Positive nondecreasing solutions for a multi-term fractional-order functional differential equation with integral conditions

Electronic Journal of Differential Equations, 2011
In this article, we prove the existence of positive nondecreasing solutions for a multi-term fractional-order functional differential equations. We consider Cauchy boundary problems with: nonlocal conditions, two-point boundary conditions, integral ...
Ahmed M. A. El-Sayed, Ebtisam O. Bin-Taher   +1 more
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Implementation of boundary conditions for optimized high-order compact schemes [PDF]

, 1997
The optimized high-order compact (OHOC) finite difference schemes, proposed as central schemes are used for aeroacoustic computations on interior nodes.
Kim, J.W., Lee, D.J.
core   +1 more source

On Caputo–Riemann–Liouville Type Fractional Integro-Differential Equations with Multi-Point Sub-Strip Boundary Conditions

Mathematics, 2020
In this paper, we derive existence and uniqueness results for a nonlinear Caputo–Riemann–Liouville type fractional integro-differential boundary value problem with multi-point sub-strip boundary conditions, via Banach and Krasnosel’skii⏝’s fixed point ...
Ahmed Alsaedi, Amjad F. Albideewi, Sotiris K. Ntouyas, Bashir Ahmad   +3 more
doaj   +1 more source