Results 51 to 60 of about 15,176,596 (284)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Solvability of a sixth‐order boundary value problem with multi‐point and multi‐term integral boundary conditions

Mathematical Methods in the Applied Sciences
This paper aims to investigate the existence and uniqueness of solutions for a sixth‐order differential equation involving nonlocal and integral boundary conditions. Firstly, we obtain the properties of the relevant Green's functions. The existence result of at least one nontrivial solution is obtained by applying the Krasnoselskii–Zabreiko fixed point
Faouzi Haddouchi, Nourredine Houari
openaire   +2 more sources

Investigation the Existence of a Solution for a Multi-Singular Fractional Differential Equation with Multi-Points Boundary Conditions

Kragujevac Journal of Mathematics, 2022
We should try to increase our abilities in solving of complicate differential equations. One type of complicate equations are multi-singular pointwise defined fractional differential equations. We investigate the existence of solutions for a multi-singular pointwise defined fractional differential equation with multi-points boundary conditions.
Talaee, M., Shabibi, Mehdi, Gilani, Alireza, Rezapour, Shahram   +3 more
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Nonlinear fractional differential equations and inclusions of arbitrary order and multi-strip boundary conditions

Electronic Journal of Differential Equations, 2012
We study boundary value problems of nonlinear fractional differential equations and inclusions of order $q in (m-1, m]$, $m ge 2$ with multi-strip boundary conditions.
Bashir Ahmad, Sotiris K. Ntouyas
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Solutions for the Cahn-Hilliard Equation With Many Boundary Spike Layers [PDF]

, 2001
In this paper we construct new classes of stationary solutions for the Cahn-Hilliard equation by a novel approach. One of the results is as follows: Given a positive integer K and a (not necessarily nondegenerate) local minimum point of the mean
Winter, M, Wei, J
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Fractional Differential Equation Involving Mixed Nonlinearities with Nonlocal Multi-Point and Riemann-Stieltjes Integral-Multi-Strip Conditions

Fractal and Fractional, 2019
In this paper, we investigate a new class of boundary value problems involving fractional differential equations with mixed nonlinearities, and nonlocal multi-point and Riemann−Stieltjes integral-multi-strip boundary conditions.
Bashir Ahmad, Ahmed Alsaedi, Sara Salem, Sotiris K. Ntouyas   +3 more
doaj   +1 more source