Results 31 to 40 of about 92,639 (261)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Existence of positive solutions for a semipositone discrete boundary value problem
Nonlinear Analysis, 2019 We investigate the existence of positive solutions for a nonlinear second-order difference equation with a linear term and a sign-changing nonlinearity, supplemented with multi-point boundary conditions.
Rodica Luca
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Existence of three solutions for sytems of multi-point boundary value problems
Electronic Journal of Qualitative Theory of Differential Equations, 2009 By using a variational approach, we obtain some sufficient conditions for the existence of three classical solutions of a boundary value problem consisting of a system of differential equations and some multi-point boundary conditions.
Zengji Du, Lingju Kong
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
On a system of higher-order multi-point boundary value problems
Electronic Journal of Qualitative Theory of Differential Equations, 2012 We investigate the existence and nonexistence of positive solutions for a system of nonlinear higher-order ordinary differential equations subject to some multi-point boundary conditions.
Johnny Henderson, Rodica Luca
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Existence of three solutions for a higher-order boundary-value problem
Electronic Journal of Differential Equations, 2009 We consider a higher-order multi-point boundary-value problem with a nonlinear boundary condition. Sufficient conditions are obtained for the existence of three solutions.
John R. Graef, Lingju Kong, Qingkai Kong
doaj
Positive solutions for a system of second-order discrete boundary value problems
Advances in Difference Equations, 2018 We study the existence and multiplicity of positive solutions for a system of nonlinear second-order difference equations subject to multi-point boundary conditions, under some assumptions on the nonlinearities of the system which contains concave ...
Ravi P. Agarwal, Rodica Luca
doaj +1 more source