Results 41 to 50 of about 92,639 (261)

Solvability of a sixth‐order boundary value problem with multi‐point and multi‐term integral boundary conditions

Mathematical Methods in the Applied Sciences
This paper aims to investigate the existence and uniqueness of solutions for a sixth‐order differential equation involving nonlocal and integral boundary conditions. Firstly, we obtain the properties of the relevant Green's functions. The existence result of at least one nontrivial solution is obtained by applying the Krasnoselskii–Zabreiko fixed point
Faouzi Haddouchi, Nourredine Houari
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

RIEMANN–LIOUVILLE FRACTIONAL INTEGRO-DIFFERENTIAL EQUATIONS WITH FRACTIONAL NONLOCAL MULTI-POINT BOUNDARY CONDITIONS

Fractals, 2021
In this paper, we investigate the existence and uniqueness of solutions for Riemann–Liouville fractional integro-differential equations equipped with fractional nonlocal multi-point and strip boundary conditions in the weighted space. The methods of our study include the well-known tools of the fixed point theory, which are commonly applied to ...
Ahmad, Bashir, Alghamdi, Badrah, Agarwal, Ravi P., Alsaedi, Ahmed   +3 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Nonlinear fractional differential equations and inclusions of arbitrary order and multi-strip boundary conditions

Electronic Journal of Differential Equations, 2012
We study boundary value problems of nonlinear fractional differential equations and inclusions of order $q in (m-1, m]$, $m ge 2$ with multi-strip boundary conditions.
Bashir Ahmad, Sotiris K. Ntouyas
doaj  

Coupled Systems of Nonlinear Integer and Fractional Differential Equations with Multi-Point and Multi-Strip Boundary Conditions

Mathematics, 2020
We first consider a second order coupled differential system with nonlinearities involved two unknown functions and their derivatives, subject to a new kinds of multi-point and multi-strip boundary value conditions.
Bin Di, Guo Chen, Huihui Pang
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

On (k,ψ)-Hilfer Fractional Differential Equations and Inclusions with Mixed (k,ψ)-Derivative and Integral Boundary Conditions

Axioms, 2022
In this paper we study single-valued and multi-valued (k,ψ)-Hilfer-type boundary value problems of fractional order in (1,2], subject to nonlocal boundary conditions involving (k,ψ)-Hilfer-type derivative and integral operators.
Sotiris K. Ntouyas, Bashir Ahmad, Cholticha Nuchpong, Jessada Tariboon   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source