Results 91 to 100 of about 1,104,621 (268)

Pioneering ML-driven framework for in-situ vertical surface roughness prediction in LPBF

Virtual and Physical Prototyping
Real-time prediction of vertical surface roughness in laser powder bed fusion (LPBF) is essential for process control and quality assurance, yet it remains largely unexplored due to view-blocking by loose powder in the machine bed.
Sahar Toorandaz, Farima Liravi, Osazee Ero, Ehsan Toyserkani   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Method for Improving Permeability Accuracy of Tight Sandstone Gas Reservoirs Based on Core Data and NMR Logs

Energies, 2019
Accurate calculation of the permeability of tight sandstone gas reservoirs has been a challenge, due to the enhanced effect of pore structure. Reservoir permeability with the same porosity and different pore structure often varies greatly.
Liang Liu, Heping Pan, Chengxiang Deng, Guoshu Huang   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Flexible and Highly Sensitive Pressure Sensors Based on Microstructured Carbon Nanowalls Electrodes

Nanomaterials, 2019
Wearable pressure sensors have attracted widespread attention in recent years because of their great potential in human healthcare applications such as physiological signals monitoring.
Xi Zhou, Yongna Zhang, Jun Yang, Jialu Li, Shi Luo, Dapeng Wei   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

An integrated fuzzy logic and machine learning platform for porosity detection using optical tomography imaging during laser powder bed fusion

International Journal of Extreme Manufacturing
Traditional methods such as mechanical testing and x-ray computed tomography (CT), for quality assessment in laser powder-bed fusion (LPBF), a class of additive manufacturing (AM), are resource-intensive and conducted post-production. Recent advancements
Osazee Ero, Katayoon Taherkhani, Yasmine Hemmati, Ehsan Toyserkani   +3 more
doaj   +1 more source

Frequency-Dependent Scaling Factors to Estimate Multiple Time-Period Global Mass Changes Observed by GRACE/GRACE-FO

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The scaling factor method is commonly used to restore near-true time-variable gravity from gravity recovery and climate experiment/follow-on (GRACE/GRACE-FO).
Zhenran Peng, Linsong Wang, Qing Liang, Chao Chen   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Multi-scale Sparse Domination

Memoirs of the American Mathematical Society
We prove a bilinear form sparse domination theorem that applies to many multi-scale operators beyond Calderón–Zygmund theory, and also establish necessary conditions. Among the applications, we cover large classes of Fourier multipliers, maximal functions, square functions and variation norm operators.
Beltran Portales, David, Roos, Joris, Seeger, Andreas   +2 more
openaire   +3 more sources