Results 81 to 90 of about 6,631,135 (316)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The role of gravity or pressure and contact stiffness in granular rheology

New Journal of Physics, 2015
The steady-state shear rheology of granular materials is investigated in slow quasistatic and inertial flows. The effect of gravity (thus the local pressure) and the often-neglected contact stiffness are the focus of this study.
Abhinendra Singh, Vanessa Magnanimo, Kuniyasu Saitoh, Stefan Luding   +3 more
doaj   +1 more source

Multi-scale modeling of dense gas-particle flows

, 2012
Dense gas-particle flows are encountered in a variety of industrially important processes for large scale production of fuels, fertilizers and base chemicals.
Kuipers, J.A.M.; id_orcid, Kuipers, JAM Hans, Kuipers, J.A.M.   +2 more
core  

Multi-scale underwater descattering

2016 23rd International Conference on Pattern Recognition (ICPR), 2016
Underwater images suffer from severe perceptual/visual degradation, due to the dense and non-uniform medium, causing scattering and attenuation of the propagated light that is sensed. Typical restoration methods rely on the popular Dark Channel Prior to estimate the light attenuation factor, and subtract the back-scattered light influence to invert the
Ancuti, Cosmin, Ancuti, Codruta O., De Vleeschouwer, Christophe, Garcia, Rafael, Bovik, Alan C., 2016 23rd International Conference on Pattern Recognition (ICPR)   +5 more
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Collaborative soil moisture inversion with multi-source remote sensing data [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Soil moisture is a key variable in the global water cycle, carbon balance and energy conversion, and is crucial for hydrological control, meteorological forecasting and crop growth. Pengyang County in Ningxia is a typical region with fragile ecology.
X. Chang, L. Xu, S. Liu, D. Liao
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Biocompatible Magnetopyroelectric Composite Films for Cell Stimulation

Advanced Science
Magnetoelectric materials, which generate electric fields in response to alternating magnetic stimulation, are increasingly recognized for their applications in neuromodulation, tissue engineering, wireless drug delivery, and cancer treatment. This study
Hao Ye, Joaquin Llacer‐Wintle, Semih Sevim, Elric Zhang, Denis vonArx, Lukas Hertle, Martina Accursi, Minsoo Kim, Josep Puigmartí‐Luis, Bradley J. Nelson, Xiang‐Zhong Chen, Salvador Pané   +11 more
doaj   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
Kierzek, A.M., Eriko Takano (50986), Breitling, Rainer, Albert Gevorgyan, Gevorgyan, A., Breitling, R., Breitling, Rainer,, Andrzej M Kierzek, Zakrzewski, Piotr, Breitling Rainer, Gevorgyan Albert, Piotr Zakrzewski (111739), Piotr Zakrzewski, Rainer Breitling (4371), Eriko Takano, Medema, M.H., Takano, Eriko,, Zakrzewski Piotr, Gevorgyan, Albert, Takano Eriko, Kierzek, Andrzej M., Zakrzewski, P., Takano, E., Rainer Breitling, Medema Marnix H., Gevorgyan, Albert,, Marnix H. Medema (111741), Medema, Marnix H.,, Medema, Marnix H., Albert Gevorgyan (111745), Andrzej M. Kierzek (111748), Kierzek Andrzej M., Takano, Eriko, Zakrzewski, Piotr,, Marnix H Medema, Takano, Eriko; id_orcid, Kierzek, Andrzej M.,   +36 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source