Results 51 to 60 of about 9,427,858 (262)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effect of pH on the surface charges of permanently/variably charged soils and clay minerals

Scientific Reports
Traditionally, the surface charge number (SCN) of permanently charged soils/clay minerals is believed to be unaffected by environmental pH. However, recent studies have revealed the occurrence of polarization-induced covalent bonding between H+ and the ...
Hua Cao, Xinmin Liu, Bo Feng, Jiaqi Sun, Deyuan Ma, Xijing Chen, Hang Li   +6 more
doaj   +1 more source

A Terahertz Polarizer Based on Multilayer Metal Grating Filled in Polyimide Film

IEEE Photonics Journal, 2016
Terahertz (THz) polarizers with low reflection and absorption loss and high polarization extinction ratio (PER) based on multilayer metallic gratings filled in a polyimide film were studied theoretically and experimentally.
Hong-Yan Mao, Liang-Ping Xia, Xian-Hua Rao, Hong-Liang Cui, Si-Jiang Wang, Yun-Sheng Deng, Dong-Shan Wei, Jun Shen, Hong-Mei Xu, Chun-Lei Du   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Multi-scale place recognition with multi-scale sensing [PDF]

, 2015
Most robot navigation systems perform place recognition using a single sensor modality and using one, or at most two heterogeneous map scales. In contrast, mammals likely per- form navigation by combining sensing from a wide variety of modalities ...
Rallabandi, Venkateswara Rao, Milford, Michael, Jacobson, Adam, Chen, Zetao   +3 more
core  

Ultrasound-mediated piezoelectric differentiation of neuron-like PC12 cells on PVDF membranes

Scientific Reports, 2017
Electrical and/or electromechanical stimulation has been shown to play a significant role in regenerating various functionalities in soft tissues, such as tendons, muscles, and nerves. In this work, we investigate the piezoelectric polymer polyvinylidene
Marcus Hoop, Xiang-Zhong Chen, Aldo Ferrari, Fajer Mushtaq, Gagik Ghazaryan, Theo Tervoort, Dimos Poulikakos, Bradley Nelson, Salvador Pané   +8 more
doaj   +1 more source

A Pixilated Spectrometer Based on Single Liquid Crystal and Sparse Algorithm

IEEE Photonics Journal, 2016
A method of achieving integrated microspectrometer with small size, high-energy efficiency, and high spectrum resolution is proposed. This spectrometer utilizes the single-pixilated liquid crystal (LC) and a matched sparse representation algorithm.
Feiying Sun, Liangping Xia, Zheng Yang, Jun Cui, Ziyin Zhang, Chang bin Nie, Danjun Liu, Shaoyun Yin, Guoxing Zheng, Peng Wu, Ruofu Yang, Chunlei Du   +11 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source