Results 41 to 50 of about 74,666 (264)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A Multi‐Scale Time Adaptive Fusion Network for Transformer Fault Diagnosis

Engineering Reports
Transformer fault diagnosis is crucial for the safe operation of power systems, enabling quick and accurate fault type identification. However, traditional methods struggle with extracting multi‐scale temporal features and high‐order feature ...
XuMing Liu, XiaoKun He, YongLin Li
doaj   +1 more source

Polarized image fusion strategy based on multi-scale feature fusion

Optics Express
Polarized image fusion aims to combine multi-scale polarization data to generate images with improved texture and intensity details. To enhance the extraction and preservation of complementary information from source images, we propose a novel fusion strategy based on a Dense Generative Adversarial Network (D-GAN).
Junxiang Liu, Zhenmin Zhu, Wei Li, Wenquan Lu, Zhenhua Xu   +4 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

AAMS-YOLO: enhanced farmland parcel detection for high-resolution remote sensing images

International Journal of Digital Earth
Detecting farmland parcels in high-resolution remote sensing images is challenging in smallholder farming systems in China, characterized by fragmented plots, irregular shapes, and varying scales.
Binyao Wang, Ya’nan Zhou, Weiwei Zhu, Li Feng, Jinke He, Tianjun Wu, Jiancheng Luo, Xin Zhang   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Object Detection in Remote Sensing Images Based on Adaptive Multi-Scale Feature Fusion Method

Remote Sensing
Multi-scale object detection is critical for analyzing remote sensing images. Traditional feature pyramid networks, which are aimed at accommodating objects of varying sizes through multi-level feature extraction, face significant challenges due to the ...
Chun Liu, Sixuan Zhang, Mengjie Hu, Qing Song   +3 more
doaj   +1 more source

Scale Enhancement Pyramid Network for Small Object Detection from UAV Images

Entropy, 2022
Object detection is challenging in large-scale images captured by unmanned aerial vehicles (UAVs), especially when detecting small objects with significant scale variation.
Jian Sun, Hongwei Gao, Xuna Wang, Jiahui Yu   +3 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source