Results 131 to 140 of about 20,830,634 (309)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Construction and application of multi-scale 3D geological models: an example from Qingdao City, China

Frontiers in Earth Science
The 3D geological model serves as a cornerstone, establishing the essential foundation and prerequisite for numerical simulations, analytical assessments, and evaluative procedures that are integral to the disciplines of geotechnical and geological ...
Dong Ji, Dong Ji, Dong Ji, Jing Hou, Zhiliang Cheng, Zhiliang Cheng, Shuai Wei, Shuai Wei, Yue Zhai, Wenhao Li, Wenhao Li   +10 more
doaj   +1 more source

An integrative, multi‐scale, genome‐wide model reveals the phenotypic landscape of Escherichia coli

Molecular Systems Biology, 2014
Given the vast behavioral repertoire and biological complexity of even the simplest organisms, accurately predicting phenotypes in novel environments and unveiling their biological organization is a challenging endeavor.
Javier Carrera, Raissa Estrela, Jing Luo, Navneet Rai, Athanasios Tsoukalas, Ilias Tagkopoulos   +5 more
doaj   +1 more source

Optimizing Dosage-Specific Treatments in a Multi-Scale Model of a Tumor Growth. [PDF]

Front Mol Biosci, 2022
Ponce-de-Leon M, Montagud A, Akasiadis C, Schreiber J, Ntiniakou T, Valencia A.   +5 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Fragility Assessment and Reinforcement Strategies for Transmission Towers Under Extreme Wind Loads

Applied Sciences
Transmission towers are particularly vulnerable to extreme wind events, which can lead to structural damage or collapse, thereby compromising the stability of power transmission systems.
Lanxi Weng, Jiaren Yi, Fubin Chen, Zhenru Shu   +3 more
doaj   +1 more source

Investigating the spatial resolution of EMG and MMG based on a systemic multi-scale model. [PDF]

Biomech Model Mechanobiol, 2022
Klotz T, Gizzi L, Röhrle O.
europepmc   +1 more source

Multi-scale computational fluid dynamics for dense gas-solid flows using DEM as numerical laboratory [PDF]

, 2007
No ...
van Sint Annaland, M., Hoef, van der, M.A., Kuipers, J.A.M.; id_orcid, van der Hoef, Martin Anton, Kuipers, JAM Hans, Deen, N.G., Deen, NG Niels, Sint Annaland, M Martin van, Kuipers, J.A.M., Sint Annaland, van, M., Hoef, MA Martin van der, Deen, N.G.; id_orcid   +11 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Erratum: Knowledge Representation for Multi-Scale Physiology Route Modeling

Frontiers in Neuroinformatics, 2022
Frontiers Production Office
doaj   +1 more source