Results 21 to 30 of about 2,589,900 (302)
Scientific Reports, 2021 There is an urgent need to identify novel biomarkers that predict the prognosis of patients with NSCLC. In this study,we aim to find out mRNA signature closely related to the prognosis of NSCLC by new algorithm of bioinformatics. Identification of highly
Nan Ma +4 more
doaj +1 more source
Soft sweeps III: The signature of positive selection from recurrent mutation [PDF]
, 2006 Polymorphism data can be used to identify loci at which a beneficial allele has recently gone to fixation, given that an accurate description of the signature of selection is available. In the classical model that is used, a favored allele derives from a
Pleuni S. Pennings +4 more
core +1 more source
Frontiers in Molecular Biosciences, 2023 Background: Rare endocrine cancers such as Adrenocortical Carcinoma (ACC) present a serious diagnostic and prognostication challenge. The knowledge about ACC pathogenesis is incomplete, and patients have limited therapeutic options.
Roberto Martin-Hernandez +6 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
IEEE AccessIn the charity sector, fundraising and transparency have long been key issues. Charity NFT (Non-Fungible Token) auctions, an emerging charity fundraising model integrating blockchain and NFT concepts, bring opportunities and challenges.
Chin-Ling Chen +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Secure Threshold Ring Signature Based on SM9
IEEE Access, 2021 Nowadays, it becomes a major issue that has become increasingly prominent to ensure the privacy and security of information. With the wide application of SM9 algorithm in various fields, it is particularly important to improve the security of SM9 ...
Shuanggen Liu +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
On Key Substitution Attacks Against Aggregate Signatures and Multi-Signatures
IEEE AccessThe most fundamental security requirement for signature schemes is unforgeability, which guarantees that no one can create a valid signature on a message without the secret signing key.
Yuuki Fujita +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source