Results 91 to 100 of about 8,052,059 (334)

Erlang Strength Model for Exponential Effects

Open Physics, 2015
All technical systems have been designed to perform their intended tasks in a specific ambient. Some systems can perform their tasks in a variety of distinctive levels.
Gökdere Gökhan, Gürcan Mehmet
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Research of mission success importance for a multi-state repairable -out-of- system

Advances in Mechanical Engineering, 2018
For the reliability analysis of complex equipment system, one of the key objectives is that the equipment can complete the specified mission as expected.
Jiang-Bin Zhao, Pei-Yong Hou, Zhi-Qiang Cai, Yang Li, Peng Guo   +4 more
doaj   +1 more source

Multi-state reliability requirements for complex systems [PDF]

2008 Annual Reliability and Maintainability Symposium, 2008
Few complex systems exhibit a binary set of states, that is only simple systems are limited to the basic states of operational and failed. Complex systems and Systems of Systems (SoS) take on multiple degraded states between the fully operational and fully failed extremes.
openaire   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

We are still in it: a conceptual model for moral injury and burnout in alternative response programs to guide intervention

Frontiers in Psychiatry
IntroductionAbout 20% of police calls involve a person experiencing a behavioral health crisis. To better address these community member’s needs and reduce risk of harm, jurisdictions are developing programs that shift calls for crises related to ...
Miranda Worthen, Soma De Bourbon, Omar Breedlove, Courtney Ewing, Joseph Graterol, Joseph Graterol, Amelia Harmon, Nakia Hines, Erik Lundgren, Michael Mason, Michael Marchiselli, Vania Mendoza, Khoa Nguyen, Britt Rubin, April Sloan, Shira Maguen, Shira Maguen   +16 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Unit Commitment Accommodating Large Scale Green Power

Applied Sciences, 2019
As more clean energy sources contribute to the electrical grid, the stress on generation scheduling for peak-shaving increases. This is a concern in several provinces of China that have many nuclear power plants, such as Guangdong and Fujian.
Yuntao Ju, Jiankai Wang, Fuchao Ge, Yi Lin, Mingyu Dong, Dezhi Li, Kun Shi, Haibo Zhang   +7 more
doaj   +1 more source