Results 111 to 120 of about 35,410,931 (299)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Research on a Miniature Underwater Vehicle Based on a Multi-Unit Underwater Coupled Jet Drive

Actuators
The underwater unstructured environment poses new challenges for the miniaturization and flexibility of underwater vehicles. This paper proposes a method of using micrometer-scale vibrations of piezoelectric vibrators to drive macroscopic jets.
Dong Zhang, Xingming Ma, Xue Zhang, Peng Gao, Kai Li   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The effect of the active carbonyl groups and residual acid on the ammonia adsorption over the acid-modified activated carbon

Frontiers in Environmental Science, 2023
Changming Li, Shuying Zhao, Shuying Zhao, Ming Li, Zhiliang Yao, Yang Li, Chuanqiang Zhu, Si-Min Xu, Junjie Li, Jian Yu   +9 more
doaj   +1 more source

Strengthened ENSO Amplitude Contributed to Regime Shift in the Hadley Circulation

Geophysical Research Letters
Understanding the variability in the Hadley circulation (HC) changes is crucial for understanding ocean‐atmosphere interactions. In this study, the variability in the boreal winter HC in the last 4 decades is explored using multiple reanalyzes and model ...
Juan Feng, Shuang Wang, Jianping Li
doaj   +1 more source

Family And Domestic Violence in Nigeria: A Study of The Niger Delta Region, 2000-2023

Shodh Sari
This study examines the risk factors, impact and ways to mitigate family and domestic violence in the Niger Delta region of Nigeria from year 2000 to 2023.
Dr Odeigah Theresa Nfam, Abdulsalami Muyideen Deji, Joel, Kerimu Ikazuwagbe, Orji Boniface Ifeanyi, Odeigah Odiakaose Praise, Awosika, Omolola Justinah   +5 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source