Results 91 to 100 of about 35,403,252 (299)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Data-intensive task scheduling in geo-distributed cloud computing: a deep reinforcement learning approach

Journal of Cloud Computing: Advances, Systems and Applications
Geo-distributed clouds have become an increasingly common architecture in modern cloud computing. By placing data centers in multiple geographical regions, cloud service providers shorten the distance between users and cloud resources, enabling low ...
Zhaoze Liu, Yajuan Sun, Cong Liu, Zhiming Zhao, Long Cheng   +4 more
doaj   +1 more source

Structure of Multi-State Correlation in Electronic Systems

Journal of Chemical Theory and Computation
Beyond the Hohenberg-Kohn density functional theory for the ground state, it has been established that the Hamiltonian matrix for a finite number (N) of lowest eigenstates is a matrix density functional. Its fundamental variable─the matrix density D(r)─can be represented by, or mapped to, a set of auxiliary, multiconfigurational wave functions ...
Yangyi Lu, Jiali Gao
openaire   +2 more sources

A heuristic policy for maintaining multiple multi-state systems

Reliability Engineering & System Safety, 2020
Abstract This work is concerned with the optimal allocation of limited maintenance resources among a collection of competing multi-state systems, and the dynamic of each multi-state system is modelled by a Markov chain. Determining the optimal dynamic maintenance policy is prohibitively difficult, and hence we propose a heuristic dynamic maintenance ...
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Connecticut State University System [web site] [Harvested on 2011: Apr. 25]

, 2011
Updated irregularly; Title from home page (publisher's Web site, viewed Apr. 15, 2011).; Official website of the Connecticut State University System.

core   +1 more source

Connecticut State University System [web site] [Harvested on 2011: Jan. 5]

, 2011
Updated irregularly; Title from home page (publisher's Web site, viewed Apr. 15, 2011).; Official website of the Connecticut State University System.

core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Other title: Kansas Multi-Tier System of Supports

, 2009
Kansas Multi-Tier System of Supports is funded by Kansas State Department of Education Special Education Services Individual with Disabilities Education Act, Part B Federal Funds.A set of 4 documents provided by Special Education Services, Kansas State ...
Kansas. State Department of Education. Special Education Services.
core   +1 more source