Results 101 to 110 of about 8,052,059 (334)
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
IEEE Access, 2019 Motivated by the need to reduce the maintenance cost and improve the system reliability, the issue of selective maintenance has attracted much attention in the industrial and military fields.
Yusheng Wang, Ehsan Elahi, Lei Xu
doaj +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Design of sensing system of multi-target motion state based on DM642
Gong-kuang zidonghua, 2015 In view of defects of false alarm and fail alarm existed in coal mine video monitoring of moving target by artificial methods, a design scheme of sensing system of multi-target motion state based on DM642 was proposed.
HUA Gang +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Multi-State System Reliability: A New and Systematic Review
, 2012 Reliability analysis considering multiple possible states is known as multi-state (MS) reliability analysis. Multi-state system reliability models allow both the system and its components to assume more than two levels of performance. Through multi-state
Yingkui Gu, Li Jing
semanticscholar +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Research on a Miniature Underwater Vehicle Based on a Multi-Unit Underwater Coupled Jet Drive
ActuatorsThe underwater unstructured environment poses new challenges for the miniaturization and flexibility of underwater vehicles. This paper proposes a method of using micrometer-scale vibrations of piezoelectric vibrators to drive macroscopic jets.
Dong Zhang +4 more
doaj +1 more source