Results 91 to 100 of about 134,390 (294)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Unpaired Multi-View Graph Clustering with Cross-View Structure Matching [PDF]

, 2023
Multi-view clustering (MVC), which effectively fuses information from multiple views for better performance, has received increasing attention. Most existing MVC methods assume that multi-view data are fully paired, which means that the mappings of all ...
Liang, Weixuan, Wang, Siwei, Liao, Qing, Liang, Ke, Wan, Xinhang, Wen, Yi, Liu, Xinwang   +6 more
core   +1 more source

Tensioned Multi-View Ordered Kernel Subspace Clustering

Applied Sciences
Multi-view data improve the effectiveness of clustering tasks, but they often encounter complex noise and corruption. The missing view of the multi-view samples leads to serious degradation of the clustering model’s performance.
Liping Chen, Gongde Guo
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Ensemble clustering via heuristic optimisation [PDF]

, 2010
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel UniversityTraditional clustering algorithms have different criteria and biases, and there is no single algorithm that can be the best solution for a wide range of ...
Jian Li, Li, Jian
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Co-clustering of multi-view datasets [PDF]

, 2016
In many clustering problems, we have access to multiple sources of data representing different aspects of the problem. Each of these data separately represents an association between entities.
Hussain, Syed Fawad; id_orcid, Bashir, Shariq   +1 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Multi-View Information-Theoretic Co-Clustering for Co-Occurrence Data [PDF]

, 2019
Multi-view clustering has received much attention recently. Most of the existing multi-view clustering methods only focus on one-sided clustering. As the co-occurring data elements involve the counts of sample-feature co-occurrences, it is more efficient
Xu, Peng, Choi, K-S, Xu, P, Deng, Z, Choi, Kup-Sze, Cao, L, Deng, Zhaohong, Cao, Longbing, Wang, Shitong, Wang, S   +9 more
core   +1 more source