Results 91 to 100 of about 8,584,032 (293)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Multi-Attribute Decision Making with Weighted Description Logics.
FLAP, 2017 We introduce a decision-theoretic framework based on Description Logics (DLs), which can be used to encode and solve single stage multi-attribute de- cision problems. In particular, we consider the background knowledge as a DL knowledge base where each attribute is represented by a concept, weighted by a utility value which is asserted by the user ...
Acar, Erman +4 more
openaire +3 more sources
Anchoring bias in eliciting attribute weights and values in multi-attribute decision-making
, 2020 The aim of this study is to look at anchoring bias–one of the main cognitive biases–in two multi-attribute decision-making methods, SMART and Swing. First, the existence of anchoring bias in these two methods for eliciting attribute weights and attribute
Rezaei, J., Rezaei, J. (author)
core +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Modelling and optimizing multiple attribute decisions by using fuzzy sets [PDF]
The purpose of this paper is to present a coherent perspective of modeling and optimizing multiple attribute decisions by using fuzzy sets. In management practice we face most of the time the situation in which a problem have several possible solutions ...
Adina NEGRUSA, Gh. Gh. IONESCU
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Optimal Multi-Attribute Decision Making in Social Choice Problems [PDF]
Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence, 2018 My thesis solves problems of decision making when alternatives are characterized by multiple attributes, under natural restrictions on agents’ preferences that are motivated by practical and cognitive considerations. Computing optimal decisions in these settings is often hard in general.
openaire +3 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Multi-Attribute Decision-Making Model by Applying Grey Numbers
Informatica, 2009 Multi-attribute analysis is a useful tool in many economical, managerial, constructional, etc. problems. The accuracy of performance measures in COPRAS (The multi-attribute COmplex PRoportional ASsessment of alternatives) method is usually assumed to be accurate. This method assumes direct and proportional dependence of the weight and utility degree of
Zavadskas, Edmundas Kazimieras +3 more
openaire +3 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source