Results 51 to 60 of about 214,797 (283)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Digital Twin-Enabled Decision Support in Mission Engineering and Route Planning

Systems, 2021
This article presents a Model-Based Systems Engineering (MBSE) methodology for the development of a Digital Twin (DT) for an Unmanned Aerial System (UAS) with the ability to demonstrate route selection capability with a Mission Engineering (ME) focus. It
Eugene Boon Kien Lee, Douglas L. Van Bossuyt, Jason F. Bickford   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Noncompensatory Consideration and Compensatory Choice : an Application to Stackelberg Competition [PDF]

, 2014
I would like to thank Ran Spiegler for his helpful suggestions. I am also grateful to Miguel Angel Ballester, Johannes Hoerner, Philippe Jehiel, Erika Magnago, Paola Manzini, Marco Mariotti, William Neilson, an anonymous referee, the editor Nicholas C ...
Papi, Mauro
core   +1 more source

Implementasi Metode Multi Attribute Utility Theory Pemberian Komisi Untuk Sales

Journal Of Computer Science And Technology (JOCSTEC), 2023
Dalam pemberian komisi pada CV. Sempurna Tetap Makmur terdapat beberapa kriteria yang menjadi penilaian. Dalam mengambil keputusan terhadap penentuan komisi pada CV. Sempurna Tetap Makmur sudah menerapkan sistem terkomputerisasi dengan menggunakan Microsoft Excel dan untuk pengembangan aplikasi penentuan komisi maka CV.
null Bambang Hardian Syahputra, null Irianto Irianto, null Febri Dristyan   +2 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On Estimating Multi-Attribute Choice Preferences using Private Signals and Matrix Factorization

, 2018
Revealed preference theory studies the possibility of modeling an agent's revealed preferences and the construction of a consistent utility function. However, modeling agent's choices over preference orderings is not always practical and demands strong ...
Langbort, Cedric, Nadendla, Venkata Sriram Siddhardh   +1 more
core   +1 more source

A view from the Bridge: agreement between the SF-6D utility algorithm and the Health utilities Index [PDF]

, 2003
BACKGROUND: The SF-6D is a new health state classification and utility scoring system based on 6 dimensions (‘6D’) of the Short Form 36, and permits a ‘‘bridging’’ transformation between SF-36 responses and utilities. The Health Utilities Index, mark 3
Brazier, Brazier, Drummond, Drummond, Feeny, Feeny, Fryback, Hohnloser, Keeney, Kind, Nichol, Samsa, Torrance, Ware, Ware   +14 more
core   +1 more source

Metode Multi Attribute Utility Theory (MAUT) dalam Keputusan Pengendalian Persediaan Obat dan Alat Kesehatan

Jurnal Informatika Ekonomi Bisnis, 2022
Medicines and medical devices are one of the most important parts of a health service, so it is necessary to guarantee the availability of drugs and medical devices for treatment so that the process can run effectively and efficiently.
Retchi Puspita
semanticscholar   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source