Results 51 to 60 of about 7,458 (257)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Selecting essential information for biosurveillance--a multi-criteria decision analysis.

PLoS ONE, 2014
The National Strategy for Biosurveillance defines biosurveillance as "the process of gathering, integrating, interpreting, and communicating essential information related to all-hazards threats or disease activity affecting human, animal, or plant health
Nicholas Generous, Kristen J Margevicius, Kirsten J Taylor-McCabe, Mac Brown, W Brent Daniel, Lauren Castro, Andrea Hengartner, Alina Deshpande   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Strategi Pengembangan Usaha Cokelat Menggunakan Quantitative Strategic Planning Matrix (QSPM) dan Multi Attribute Utility Theory (MAUT) di Kampung Coklat, Blitar

Industria: Jurnal Teknologi dan Manajemen Agroindustri, 2017
Abstrak Tujuan penelitian ini adalah mengetahui faktor yang paling mempengaruhi usaha cokelat, mengetahui posisi usaha cokelat, mengetahui alternatif strategi yang tepat untuk pengembangan usaha cokelat, serta menentukan prioritas strategi.
Usman Effendi, Retno Astuti, Diana Candra Melati   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Environmental and economic implications of energy efficiency in new residential buildings: A multi-criteria selection approach

Energy Strategy Reviews, 2019
The choice of the most appropriate technologies in buildings is often a challenge at the design stage, especially when many different criteria are taken into account. Consequently, the decision process relies often on one criterion only, such as costs or
Delia D'Agostino, Danny Parker, Paco Melià   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Coherence and correspondence in engineering design: informing the conversation and connecting with judgment and decision-making research

Judgment and Decision Making, 2009
I show how the coherence/correspondence distinction can inform the conversation about decision methods for engineering design. Some engineers argue for the application of multi-attribute utility theory while others argue for what they call heuristics. To
Konstantinos V. Katsikopoulos, Philip T. Dunwoody, Robin Hogarth   +2 more
doaj   +1 more source

Analysis of Multi-attribute Utility Theory for College Ranking Decision Making

SinkrOn, 2020
Ranking of a tertiary institution, both state and private universities, can be the basis of the tertiary institutions of interest to prospective new students. The better the ranking of the college, the more popular the campus. In this study the author discusses the case of campus ranking in the city of Medan where the results to be received are the ...
Perdana, Adidtya, Budiman, Arief
openaire   +3 more sources