Results 301 to 310 of about 97,046 (344)
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The Gewald multicomponent reaction
Molecular Diversity, 2010The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component (G-3CR) yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and
Yijun, Huang, Alexander, Dömling
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Multicomponent Reactions of Cyclobutanones
The Journal of Organic Chemistry, 2009Cyclobutanones are essentially unknown as reactants in isonitrile-based multicomponent reactions. Ugi reactions of cyclobutanone and Passerini reactions of tetramethylcyclobutane-1,3-dione have been performed in this work. These reactions are significantly enhanced by being conducted in water, a subject of recent interest whose basis is still in ...
Michael C, Pirrung, Jianmei, Wang
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Desosamine in multicomponent reactions
Bioorganic & Medicinal Chemistry Letters, 2006Desosamine occurring ubiquitously in natural products is introduced into isocyanide based multicomponent reaction chemistry. Corresponding products are of potential interest for the design of novel antibiotics.
Achatz, Sepp, Dömling, Alexander
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Instant Macrocyclizations via Multicomponent Reactions
The Journal of Organic Chemistry, 2023Macrocycles fascinate chemists due to both their structure and their applications. However, we still lack efficient and sustainable synthetic methods, giving us straightforward access to them. Herein, a rapid macrocyclization utilizing a two-step, one-pot approach based on orthogonal multicomponent reaction (MCR) tactics is introduced.
Michael Fragkiadakis +6 more
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Multicomponent Reactions with Isocyanides
Angewandte Chemie, 2000Multicomponent reactions (MCRs) are fundamentally different from two-component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic-chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low-molecular druglike compounds.
, Dömling, , Ugi
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Multicomponent Reactions for Surface Modification
Macromolecular Rapid Communications, 2018AbstractModification of material surfaces with polymers is an effective method to develop applicable polymer–material composites. Recently, multicomponent reactions (MCRs) have found their roles in advanced polymer chemistry and applied in surface modification.
Haibo Wu, Yanzi Gou, Jun Wang, Lei Tao
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Nonracemizable Isocyanoacetates for Multicomponent Reactions
The Journal of Organic Chemistry, 2008Chiral ortho esters of alpha-isocyano acids were synthesized from commercially available Cbz-protected alpha-amino acids. These compounds are stable toward racemization in the Ugi 4CC in contrast to known esters of alpha-isocyano acids. Applying them in Ugi 4CC with subsequent deprotection gives access to dipeptides with preserved configuration at the ...
Alexander G, Zhdanko +1 more
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Organocatalytic Asymmetric Multicomponent Reactions
2015A review. This review outlines the applications of organocatalysis for the improvement of asym. multicomponent reactions. Addnl., applications of organocatalytic asym. multicomponent reactions in the total synthesis of both natural products and their analogs having notorious pharmaceutical and medicinal employment as well as biocidal activities has ...
Gasperi, Tecla +3 more
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Borylated reagents for multicomponent reactions
Drug Discovery Today: Technologies, 2018Over the past two decades, there has been an increasing interest in the therapeutic potential of organoboron reagents due to the discovery of bortezomib (Velcade). This has motivated synthetic chemists to develop novel routes for the preparation of heteroatom-rich boron-containing molecules (BCMs).
Joanne, Tan, Andrei K, Yudin
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Integrating biocatalysis and multicomponent reactions
Drug Discovery Today: Technologies, 2018While often multicomponent reactions (MCR) are used for the diversity-oriented synthesis of racemic (or achiral) molecular entities, this short review describes two alternative approaches for accessing enantiopure products exploiting the power of biocatalysis.
LAMBRUSCHINI, CHIARA +2 more
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