Results 321 to 330 of about 4,644,920 (368)

Desosamine in multicomponent reactions

Bioorganic & Medicinal Chemistry Letters, 2006
Desosamine occurring ubiquitously in natural products is introduced into isocyanide based multicomponent reaction chemistry. Corresponding products are of potential interest for the design of novel antibiotics.
Achatz, Sepp, Dömling, Alexander
openaire   +2 more sources

Instant Macrocyclizations via Multicomponent Reactions

The Journal of Organic Chemistry, 2023
Macrocycles fascinate chemists due to both their structure and their applications. However, we still lack efficient and sustainable synthetic methods, giving us straightforward access to them. Herein, a rapid macrocyclization utilizing a two-step, one-pot approach based on orthogonal multicomponent reaction (MCR) tactics is introduced.
Michael Fragkiadakis, Paraskevi-Kleio Anastasiou, Marios Zingiridis, Marios E. Triantafyllou-Rundell, Atilio Reyes Romero, Constantinos C. Stoumpos, Constantinos G. Neochoritis   +6 more
openaire   +2 more sources

Multicomponent Reactions with Isocyanides

Angewandte Chemie, 2000
Multicomponent reactions (MCRs) are fundamentally different from two-component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic-chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low-molecular druglike compounds.
, Dömling, , Ugi
openaire   +2 more sources

Construction of Unique Eight- or Nine-Membered Polyheterocyclic Systems via Multicomponent Reaction of l-Proline, Alkyl Propiolate, and Isatin.

Journal of Organic Chemistry, 2018
The multicomponent reaction of l-proline, isatins, and excess of methyl propiolates in methanol unexpectedly afforded 2-(oxoindolin-3-ylidene)propylidene)pyrrolidin-1-yl)acrylates in good yields, and the products subsequently converted to unique nine ...
Jun‐Jie Cao, Fan Yang, Jing Sun, Ying-Hui Huang, Chaoguo Yan   +4 more
semanticscholar   +1 more source

Multicomponent Reactions for Surface Modification

Macromolecular Rapid Communications, 2018
AbstractModification of material surfaces with polymers is an effective method to develop applicable polymer–material composites. Recently, multicomponent reactions (MCRs) have found their roles in advanced polymer chemistry and applied in surface modification.
Haibo Wu, Yanzi Gou, Jun Wang, Lei Tao
openaire   +2 more sources

Nonracemizable Isocyanoacetates for Multicomponent Reactions

The Journal of Organic Chemistry, 2008
Chiral ortho esters of alpha-isocyano acids were synthesized from commercially available Cbz-protected alpha-amino acids. These compounds are stable toward racemization in the Ugi 4CC in contrast to known esters of alpha-isocyano acids. Applying them in Ugi 4CC with subsequent deprotection gives access to dipeptides with preserved configuration at the ...
Alexander G, Zhdanko, Valentine G, Nenajdenko   +1 more
openaire   +2 more sources

Catalytic multicomponent reaction involving a ketyl-type radical

Nature Synthesis, 2022
Huan-Ming Huang, Peter Bellotti, Suhyeon Kim, Xiaolong Zhang, F. Glorius   +4 more
semanticscholar   +1 more source

Organocatalytic Asymmetric Multicomponent Reactions

2015
A review. This review outlines the applications of organocatalysis for the improvement of asym. multicomponent reactions. Addnl., applications of organocatalytic asym. multicomponent reactions in the total synthesis of both natural products and their analogs having notorious pharmaceutical and medicinal employment as well as biocidal activities has ...
Gasperi, Tecla, Orsini, Monica, Vetica, Fabrizio, de Figueiredo, Renata Marcia   +3 more
openaire   +2 more sources

Borylated reagents for multicomponent reactions

Drug Discovery Today: Technologies, 2018
Over the past two decades, there has been an increasing interest in the therapeutic potential of organoboron reagents due to the discovery of bortezomib (Velcade). This has motivated synthetic chemists to develop novel routes for the preparation of heteroatom-rich boron-containing molecules (BCMs).
Joanne, Tan, Andrei K, Yudin
openaire   +2 more sources

Integrating biocatalysis and multicomponent reactions

Drug Discovery Today: Technologies, 2018
While often multicomponent reactions (MCR) are used for the diversity-oriented synthesis of racemic (or achiral) molecular entities, this short review describes two alternative approaches for accessing enantiopure products exploiting the power of biocatalysis.
LAMBRUSCHINI, CHIARA, Andrea Basso, Luca Banfi   +2 more
openaire   +2 more sources