Results 21 to 30 of about 184,623 (248)

Multidrug-resistant Tuberculosis

Medical Clinics of North America, 2013
Multidrug-resistant tuberculosis (MDR-TB) threatens to become the dominant form of tuberculosis in many parts of the world because of decades of inappropriate treatment on a global scale. Infection with MDR-TB is associated with poor outcomes because of delays in treatment and the need for complex, toxic, and long medication regimens.
Lemos, Antônio Carlos Moreira, Matos, Eliana Dias   +1 more
openaire   +9 more sources

Prolonged carriage of OXA-244-carbapenemase-producing Escherichia coli complicates epidemiological investigations

International Journal of Medical Microbiology
The rapid increase of OXA-244-producing Escherichia coli, predominantly driven by genetically clustered isolates of sequence type (ST)38, has been observed in at least nine European countries, including Germany. However, the reasons for the spread of OXA-
Felix Reichert, Simon Brinkwirth, Niels Pfennigwerth, Sebastian Haller, Lena Sophie Fritsch, Tim Eckmanns, Guido Werner, Sören Gatermann, Jörg B. Hans   +8 more
doaj   +1 more source

An open-source nanopore-only sequencing workflow for analysis of clonal outbreaks delivers short-read level accuracy

Journal of Clinical Microbiology
In this work, we present an optimized nanopore long-read only sequencing workflow for epidemiologic analysis of clonal outbreaks built with open-source tools.
Nick Vereecke, Thomas B. Yoon, Ting L. Luo, Brendan W. Corey, Francois Lebreton, Patrick T. Mc Gann, John P. Dekker   +6 more
doaj   +1 more source

Autophagy and Transporter-Based Multi-Drug Resistance

Cells, 2012
All the therapeutic strategies for treating cancers aim at killing the cancer cells via apoptosis (programmed cell death type I). Defective apoptosis endow tumor cells with survival. The cell can respond to such defects with autophagy.
Zhe-Sheng Chen, Kurt Degenhardt, Dong-Mei Zhang, Priyank Kumar   +3 more
doaj   +1 more source

Antimicrobial Resistance Surveillance: Data Harmonisation and Data Selection within Secondary Data Use

Antibiotics
Resistance to last-resort antibiotics is a global threat to public health. Therefore, surveillance and monitoring systems for antimicrobial resistance should be established on a national and international scale.
Sinja Bleischwitz, Tristan Salomon Winkelmann, Yvonne Pfeifer, Martin Alexander Fischer, Niels Pfennigwerth, Jens André Hammerl, Ulrike Binsker, Jörg B. Hans, Sören Gatermann, Annemarie Käsbohrer, Guido Werner, Lothar Kreienbrock   +11 more
doaj   +1 more source

Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility

Nature Communications, 2022
Antibiotic resistance through multidrug efflux is a major hurdle in antibiotic development. Here, authors experimentally demonstrate that EmrE, a small multidrug resistance efflux pump from E.
Peyton J. Spreacker, Nathan E. Thomas, Will F. Beeninga, Merissa Brousseau, Colin J. Porter, Kylie M. Hibbs, Katherine A. Henzler-Wildman   +6 more
doaj   +1 more source

Multidrug Resistance in Fungi: Regulation of Transporter-encoding Gene Expression

Frontiers in Physiology, 2014
A critical risk to the continued success of antifungal chemotherapy is the acquisition of resistance; a risk exacerbated by the few classes of effective antifungal drugs.
Sanjoy ePaul, Scott eMoye-Rowley
doaj   +1 more source

Management of Antibiotic-Resistant Helicobacter pylori Infection: Perspectives from Vietnam

Gut and Liver, 2019
Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of Helicobacter pylori primary and secondary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin ...
Vu Van Khien, Duong Minh Thang, Tran Manh Hai, Nguyen Quang Duat, Pham Hong Khanh, Dang Thuy Ha, Tran Thanh Binh, Ho Dang Quy Dung, Tran Thi Huyen Trang, Yoshio Yamaoka   +9 more
doaj   +1 more source

Risk factors for multidrug resistance in tuberculosis patients with diabetes mellitus

BMC Infectious Diseases, 2022
Objective To study the risk factors and prediction models of multidrug resistance in patients with tuberculosis and diabetes and those with a history of tuberculosis treatment.
Shuangping Li, Yalin Liang, Xinjun Hu
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source