Results 141 to 150 of about 2,438,474 (193)
Inhibitors of Multidrug Resistance (MDR) Have Affinity for MDR Substrates
Bioorganic and Medicinal Chemistry Letters, 2004 Multidrug-resistance (MDR) occurs in many bacterial species and tumour cells. MDR functions by membrane proteins which export drugs from cells, resulting in a low ineffective concentration of the drug. We have shown by molecular modelling that inhibitors of MDR have affinity for substrates of MDR transporters.
Glenn W Kaatz, Mire Zloh, Simon Gibbons
exaly +10 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
The Medicinal Chemistry of Multidrug Resistance (MDR) Reversing Drugs
Il Farmaco, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Elisabetta Teodori +2 more
exaly +4 more sources
Inhibitors of Multidrug Resistance to Antitumor Agents (MDR)
Current Medicinal Chemistry, 2002Multidrug resistance is one of the main obstacles in the chemotherapy of cancer. Its inhibition by combination of chemosensitizers with antitumor compounds is a very active field of research, since safe and potent reversal agents would be beneficial for clinical use. Most modulators act by binding to membrane transport proteins (specially P-gp and MRP)
Carmen, Avendaño, J Carlos, Menéndez
openaire +2 more sources
Multidrug resistance (MDR) genes in haematological malignancies
Cytotechnology, 1993The emergence of drug resistant cells is one of the main obstacles for successful chemotherapeutic treatment of haematological malignancies. Most patients initially respond to chemotherapy at the time of first clinical admission, but often relapse and become refractory to further treatment not only to the drugs used in the first treatment but also to a
K, Nooter, P, Sonneveld
openaire +2 more sources
Multidrug Resistance: Physiological Principles and Nanomedical Solutions [PDF]
Advanced Drug Delivery Reviews, 2013 Multidrug resistance (MDR) is a pathophysiological phenomenon employed by cancer cells which limits the prolonged and effective use of chemotherapeutic agents.
Blazej Rychlik +2 more
exaly +2 more sources
Multidrug-Resistant Tuberculosis (MDR-TB)
2018...................... The patient lived with her husband, her three children, and a very old mother-in-law. The patient was the first child of 2 siblings with a history of spontaneous birth and was assisted by a birth attendant with cry spontaneously. Her mother-in-law had the same history of the disease, i.e., the first category of pulmonary TB.
Helen McAuslane, Dominik Zenner
openaire +3 more sources
Insight on Multidrug Resistance and Nanomedicine Approaches to Overcome MDR
Critical Reviews™ in Therapeutic Drug Carrier Systems, 2020Multidrug resistance (MDR) remains a major obstacle to ensure effective chemotherapy in cancer patients. Several factors could be associated with cancer cells' drug resistance such as overexpression of P-glycoprotein (P-gp), cancer stem cells (CSCs), defect in apoptosis, mutation and alteration in DNA repair pathways, angiogenesis, autophagy, and ...
Imran Shair, Mohammad +2 more
openaire +2 more sources