Results 151 to 160 of about 2,438,474 (193)
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Gan to kagaku ryoho. Cancer & chemotherapy, 1994
Multiple drug resistance (MDR) is a major problem of current chemotherapy. Establishment of multiple drug resistant cell lines in culture and isolation of P-glycoprotein-coding MDR genes have promoted understanding of the molecular mechanisms underlying drug resistance in tumors.
M, Wada +3 more
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Multiple drug resistance (MDR) is a major problem of current chemotherapy. Establishment of multiple drug resistant cell lines in culture and isolation of P-glycoprotein-coding MDR genes have promoted understanding of the molecular mechanisms underlying drug resistance in tumors.
M, Wada +3 more
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Pyridines: Multidrug-resistant tuberculosis (MDR-TB) inhibitors
Indian Journal of Tuberculosis, 2017Mycobacterium tuberculosis (MTB) infection has become an increasing health threat due to the worldwide emergence of multidrug-resistant MTB (MDR-MTB) strain. Isoniazid (pyridine) resistance problem is a complex process and is associated with mutations in several genes. However, the emergence of isoniazid (INH) resistant M. tuberculosis strains dictates
Kavita S, Chaudhari +2 more
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Expression of the Multidrug-Resistance (MDR) Gene in Breast Cancer
Journal of Chemotherapy, 1995Of the approximately 18,000 new cases of cancer in Venezuela each year, only half can be treated with surgery and radiation. The remainder must be treated systematically using chemotherapy or biological response modifiers. It has become evident that any drug resistant human tumors express the MDR1 gene, since MDR1 RNA levels are elevated in many ...
M, Correnti +4 more
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2009
ability of cells to develop resistance to a broad range of structurally and functionally unrelated drugs after exposure to a single drug; → see also chemosensitizer.
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ability of cells to develop resistance to a broad range of structurally and functionally unrelated drugs after exposure to a single drug; → see also chemosensitizer.
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Tuberculosis Multidrug Resistance (MDR-TB)
2020Tuberculosis is an infection caused by Mycobacterium tuberculosis, and it is known to have affected humanity since the Stone Age. Since the twentieth century, it has been possible to reduce the incidence and prevalence of it. However, the number of cases with infections by mycobacteria resistant to first-line Antituberculous treatment, the challenges ...
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Assessing Oxygen Sensitivity of the Multidrug Resistance (MDR) Gene
2004Publisher Summary This chapter focuses on assessing oxygen sensitivity of the multidrug resistance (MDR) gene. A major obstacle in the development of effective cancer chemotherapy is tumor development of the multidrug resistance (MDR1) phenotype. Multiple approaches are available to study the function of MDR1/P-gp and how such functions relate to ...
Katrina M, Comerford, Sean P, Colgan
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Overcoming multidrug resistance (MDR) in cancer by nanotechnology
Science China Chemistry, 2010The emerging nanotechnology-based drug delivery holds tremendous potential to deliver chemotherapeutic drugs for treatment of multidrug resistance (MDR) cancer. This drug delivery system could improve the pharmacokinetic behavior of antitumor drugs, deliver chemotherapeutic drugs to target sites, control release of drugs, and reduce the systemic ...
HuiHui Bu, Yu Gao, YaPing Li
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Antimicrobial Resistance (AMR) and Multidrug Resistance (MDR) :
2017Based on a review of recent literature, this WIPO Global Challenges Report includes a broad overview of current approaches and consortia designed to meet the challenge of research and development (R&D) investment for new treatments. It also examines patent applications by both the public and the private sectors as an indicator of innovative ...
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Biology and modulation of multidrug resistance (MDR) in hematological malignancies
International Journal of Hematology, 2002Drug resistance is one of the most significant impediments in the treatment of hematological malignancies. There have been a number of studies on the incidence of P-GP expression in tumor cells or tissues, where detectable level of P-GP has been found in all types of hematological malignancies.
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Multidrug Resistance Mediated by MDR-ABC Transporters
2009Cancer cells are constantly being selected for survival and proliferation. During this process, tumor cells often co-opt basic physiological mechanisms to protect themselves from toxic chemotherapy. Of these mechanisms, the one that is most commonly encountered in laboratory studies is the increased cellular efflux of a broad class of cytotoxic drugs ...
Gergely Szakács +4 more
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