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The Pyruvate Dehydrogenase Multienzyme Complex
Angewandte Chemie International Edition in English, 1975AbstractThe three enzymes pyruvate dehydrogenase, dihydrolipoamide transacetylase, and dihydrolipoamide dehydrogenase constitute the pyruvate dehydrogenase multienzyme complex of E. coli; in mammals the complex also contains a kinase and a phosphatase.
Ferdinand Hucho
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DNA-directed assembly of artificial multienzyme complexes
Biochemical and Biophysical Research Communications, 2008This study aims to establish model systems for the exploration of proximity effects, occurring in natural multienzyme complexes. DNA-directed assembly of covalent conjugates of DNA oligonucleotides and Glucose Oxidase (GOX) or Horseradish peroxidase (HRP) was used to generate supramolecular complexes, in which the two enzymes were arranged with defined
Christof M Niemeyer
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Evidence supporting multienzyme complexes as metabolons: A review
International Journal of Biological MacromoleculesFungi are widespread organisms with complex multienzyme systems crucial for diverse biochemical processes. This study systematically reviewed research on multienzyme complexes, focusing on their isolation and identification, while examining their potential classification as metabolons.
Aidil Abdul Hamid, Maizom Hassan
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Proteins secreted by filamentous fungi play key roles in different aspects of their biology. The fungus Penicillium purpurogenum, used as a model organism, is able to degrade hemicelluloses and pectins by secreting a variety of enzymes to the culture ...
Alvaro Gonzalez-Vogel +2 more
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Self-Assembled Multienzyme Nanostructures on Synthetic Protein Scaffolds
Sequential enzymes in a biosynthetic pathway often self-assemble to form nanomachineries known as multienzyme complexes inside cells. Enzyme self-assembly insulates toxic intermediates, increases the efficiency of intermediate transfer, minimizes ...
Jiang Xia
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