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DNA-directed assembly of artificial multienzyme complexes
Biochemical and Biophysical Research Communications, 2008This study aims to establish model systems for the exploration of proximity effects, occurring in natural multienzyme complexes. DNA-directed assembly of covalent conjugates of DNA oligonucleotides and Glucose Oxidase (GOX) or Horseradish peroxidase (HRP) was used to generate supramolecular complexes, in which the two enzymes were arranged with defined
Joachim, Müller, Christof M, Niemeyer
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The Pyruvate Dehydrogenase Multienzyme Complex
Angewandte Chemie International Edition in English, 1975AbstractThe three enzymes pyruvate dehydrogenase, dihydrolipoamide transacetylase, and dihydrolipoamide dehydrogenase constitute the pyruvate dehydrogenase multienzyme complex of E. coli; in mammals the complex also contains a kinase and a phosphatase.
Ferdinand Hucho
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Evidence supporting multienzyme complexes as metabolons: A review
International Journal of Biological MacromoleculesFungi are widespread organisms with complex multienzyme systems crucial for diverse biochemical processes. This study systematically reviewed research on multienzyme complexes, focusing on their isolation and identification, while examining their potential classification as metabolons.
Hebah, Al-Tamimi +4 more
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Multienzyme complexes in DNA precursor biosynthesis
Advances in Enzyme Regulation, 1979Abstract Several features of DNA replication suggest the involvement of multienzyme complexes in deoxyribonucleotide biosynthesis. Such complexes could generate intracellular concentration gradients of DNA precursors, with high levels being maintained at their sites of utilization, namely, replication forks.
C K, Mathews +2 more
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The pyruvate dehydrogenase multienzyme complex
Current Opinion in Structural Biology, 1992Abstract During the review period, several structures of component enzymes and domains of enzymes of this multienzyme complex were determined. Three structures of the flavoprotein component, dihydrolipoamide dehydrogenase, became available. The structure of the core component, dihydrolipoyl acetyltransferase, can in principle be constructed from the ...
Andrea Mattevi +2 more
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Assembly of multienzyme complexes on DNA nanostructures
Nature Protocols, 2016In nature, the catalytic efficiency of multienzyme complexes highly depends on their spatial organization. The positions and orientations of the composite enzymes are often precisely controlled to facilitate substrate transport between them. Self-assembled DNA nanostructures hold great promise for organizing biomolecules at the nanoscale.
Jinglin, Fu +7 more
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