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The Pyruvate Dehydrogenase Multienzyme Complex
Angewandte Chemie International Edition in English, 1975AbstractThe three enzymes pyruvate dehydrogenase, dihydrolipoamide transacetylase, and dihydrolipoamide dehydrogenase constitute the pyruvate dehydrogenase multienzyme complex of E. coli; in mammals the complex also contains a kinase and a phosphatase.
Ferdinand Hucho
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DNA-directed assembly of artificial multienzyme complexes
Biochemical and Biophysical Research Communications, 2008This study aims to establish model systems for the exploration of proximity effects, occurring in natural multienzyme complexes. DNA-directed assembly of covalent conjugates of DNA oligonucleotides and Glucose Oxidase (GOX) or Horseradish peroxidase (HRP) was used to generate supramolecular complexes, in which the two enzymes were arranged with defined
Christof M Niemeyer
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A Multienzyme Bioreactor Based on a Chitinase Complex
Прикладная биохимия и микробиология, 2014A heterogeneous biocatalyst containing a complex of chitinolytic enzymes isolated from the culture medium of bacteria Clostridium paraputrificum on the surface of macroporous monolithic minidisc was obtained. The complex of chitinolytic enzymes was immobilized on the polymer matrix using a multistep method involving the introduction of an intermediate ...
E G, Vlakh +2 more
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Regulation of the Pyruvate Dehydrogenase Multienzyme Complex
Annual Review of Nutrition, 1993To maximize catalytic efficiency in metabolic pathways of both prokaryotic and eUkaryotic cells, enzymatic components are occasionally clustered or complexed physically. Organization of multiple catalytic functions into a single enzyme complex can be accomplished in two ways.
R H, Behal +3 more
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Self-Assembled Multienzyme Nanostructures on Synthetic Protein Scaffolds
ACS Nano, 2019 Sequential enzymes in a biosynthetic pathway often self-assemble to form nanomachineries known as multienzyme complexes inside cells. Enzyme self-assembly insulates toxic intermediates, increases the efficiency of intermediate transfer, minimizes ...
Jiang Xia, Wei KANG, Sheng Cao
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Assembly of multienzyme complexes on DNA nanostructures
Nature Protocols, 2016In nature, the catalytic efficiency of multienzyme complexes highly depends on their spatial organization. The positions and orientations of the composite enzymes are often precisely controlled to facilitate substrate transport between them. Self-assembled DNA nanostructures hold great promise for organizing biomolecules at the nanoscale.
Jinglin, Fu +7 more
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Multienzyme complexes in DNA precursor biosynthesis
Advances in Enzyme Regulation, 1979Abstract Several features of DNA replication suggest the involvement of multienzyme complexes in deoxyribonucleotide biosynthesis. Such complexes could generate intracellular concentration gradients of DNA precursors, with high levels being maintained at their sites of utilization, namely, replication forks.
C K, Mathews +2 more
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Research progress and the biotechnological applications of multienzyme complex
Applied Microbiology and Biotechnology, 2021The multienzyme complex system has become a research focus in synthetic biology due to its highly efficient overall catalytic ability and has been applied to various fields. Multienzyme complexes are formed by cascading complexes, which are multiple functionally related enzymes that continuously and efficiently catalyze the production of substrates ...
Yi Jiang +6 more
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The pyruvate dehydrogenase multienzyme complex
Current Opinion in Structural Biology, 1992Abstract During the review period, several structures of component enzymes and domains of enzymes of this multienzyme complex were determined. Three structures of the flavoprotein component, dihydrolipoamide dehydrogenase, became available. The structure of the core component, dihydrolipoyl acetyltransferase, can in principle be constructed from the ...
Andrea Mattevi +2 more
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Applied Microbiology and Biotechnology, 2010 Proteins secreted by filamentous fungi play key roles in different aspects of their biology. The fungus Penicillium purpurogenum, used as a model organism, is able to degrade hemicelluloses and pectins by secreting a variety of enzymes to the culture ...
Eduardo Callegari +2 more
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