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Regulation of the Pyruvate Dehydrogenase Multienzyme Complex
Annual Review of Nutrition, 1993To maximize catalytic efficiency in metabolic pathways of both prokaryotic and eUkaryotic cells, enzymatic components are occasionally clustered or complexed physically. Organization of multiple catalytic functions into a single enzyme complex can be accomplished in two ways.
R H, Behal +3 more
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Multienzyme Complex in Fatty Acid Biosynthesis
2023Fatty acid biosynthesis is a fundamental process that occurs in all living organisms and involves multiple reaction steps. Thus, a systematic transfer of the intermediates between the different catalytic sites is highly required for the efficient regulation of a pathway as well as for sustaining growth.
Pranesha Prabhakaran +4 more
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A Multienzyme Bioreactor Based on a Chitinase Complex
Прикладная биохимия и микробиология, 2014A heterogeneous biocatalyst containing a complex of chitinolytic enzymes isolated from the culture medium of bacteria Clostridium paraputrificum on the surface of macroporous monolithic minidisc was obtained. The complex of chitinolytic enzymes was immobilized on the polymer matrix using a multistep method involving the introduction of an intermediate ...
E G, Vlakh +2 more
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Research progress and the biotechnological applications of multienzyme complex
Applied Microbiology and Biotechnology, 2021The multienzyme complex system has become a research focus in synthetic biology due to its highly efficient overall catalytic ability and has been applied to various fields. Multienzyme complexes are formed by cascading complexes, which are multiple functionally related enzymes that continuously and efficiently catalyze the production of substrates ...
Yi Jiang +6 more
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[Symmetry of multienzyme complexes].
Molekuliarnaia biologiia, 1986A model for studying the symmetry of stable states arising from polyenzymic complex conformations is proposed. A formal scheme of submolecular structure self-assembly, on which the model is based, enables it not only to limit the class of conformations but in some cases to determine the structure of a complex in an unambigous manner. The model is shown
B N, Gol'dshteĭn +2 more
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1970
Publisher Summary This chapter discusses certain features of a few well-documented examples of multienzyme complexes. The multienzyme complexes that have been most thoroughly described are composed of two to six functionally related enzymes and have molecular weights ranging from a few hundred thousand to a few million. The particles contain definite
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Publisher Summary This chapter discusses certain features of a few well-documented examples of multienzyme complexes. The multienzyme complexes that have been most thoroughly described are composed of two to six functionally related enzymes and have molecular weights ranging from a few hundred thousand to a few million. The particles contain definite
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Multienzyme assembly of a p53 transcription complex
Nature Structural & Molecular Biology, 2007Proline isomerization of the p53 transactivation domain has a central role in coordinating kinase signaling pathways that assemble the core p53 transcription complex.
Ted R Hupp, Malcolm Walkinshaw
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Biomimetic Multienzyme Complexes Based on Nanoscale Platforms
AIChE Journal, 2012SignificanceInspired by the widely present multienzyme complexes in nature that enable highly cooperative catalytic mechanisms, we designed a biomimetic dual‐functionalized nanoparticle‐based platform for colocalizing multiple enzymes. The use of nanoscale materials together with a novel sequential colocalization approach with two model enzymes ...
Feng Jia +2 more
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Lysosomal multienzyme complex: Biochemistry, genetics, and molecular pathophysiology
2001Lysosomal enzymes sialidase (alpha-neuraminidase), beta-galactosidase, and N-acetylaminogalacto-6-sulfate sulfatase are involved in the catabolism of glycolipids, glycoproteins, and oligosaccharides. Their functional activity in the cell depends on their association in a multienzyme complex with lysosomal carboxypeptidase, cathepsin A.
A V, Pshezhetsky, M, Ashmarina
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A Multienzyme Complex for De Novo Purine Biosynthesis
1977Multienzyme complexes are defined as aggregates of different functionally related enzymes integrated into highly organized structures by non-covalent bonds. Such a structural arrangement is considered to confer a catalytic advantage in that an unstable intermediate may be transferred more efficiently from one active site to the next.
P B, Rowe +3 more
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