Results 181 to 190 of about 8,722 (211)
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A Multienzyme Complex for De Novo Purine Biosynthesis
1977Multienzyme complexes are defined as aggregates of different functionally related enzymes integrated into highly organized structures by non-covalent bonds. Such a structural arrangement is considered to confer a catalytic advantage in that an unstable intermediate may be transferred more efficiently from one active site to the next.
P B, Rowe +3 more
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Multienzyme assembly of a p53 transcription complex
Nature Structural & Molecular Biology, 2007Proline isomerization of the p53 transactivation domain has a central role in coordinating kinase signaling pathways that assemble the core p53 transcription complex.
Ted R Hupp, Malcolm Walkinshaw
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Tryptophan synthase: A multienzyme complex with an intramolecular tunnel
The Chemical Record, 2001AbstractTryptophan synthase is a classic enzyme that channels a metabolic intermediate, indole. The crystal structure of the tryptophan synthase α2β2 complex from Salmonella typhimurium revealed for the first time the architecture of a multienzyme complex and the presence of an intramolecular tunnel. This remarkable hydrophobic tunnel provides a likely
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Multienzyme Complex in Fatty Acid Biosynthesis
2023Fatty acid biosynthesis is a fundamental process that occurs in all living organisms and involves multiple reaction steps. Thus, a systematic transfer of the intermediates between the different catalytic sites is highly required for the efficient regulation of a pathway as well as for sustaining growth.
Pranesha Prabhakaran +4 more
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A multienzyme complex for CO2 fixation.
Biochemistry, 1975Acetyl-coenzyme A carboxylase from Euglena gracilis strain Z was isolated as a component of a multienzyme complex which includes phosphoenolpyruvate carboxylase and malate dehydrogenase. The multienzyme complex was shown to exist in crude extracts and was purified to a homogeneous protein with a molecular weight of 360,000 by gel filtration.
J S, Wolpert, M L, Ernst-Fonberg
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The role of multienzyme complexes in integration of cellular metabolism
Journal of Theoretical Biology, 1986The notion of the "primary block" of cellular metabolism designated as "metabolic system" is introduced. Metabolic system is defined as a metabolic pathway which corresponds to the structurally ordered multienzyme complex. The complex of glycolytic enzymes which catalyzes the anaerobic reduction of glucose-6-phosphate with production of ATP may serve ...
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A possible origin of RNA catalysis in multienzyme complexes
Origins of life and evolution of the biosphere, 1989Numerous attempts have recently been made to ascribe a preeminent role to RNA enzymes in primitive life systems. A model is proposed in which coenzyme-dependent RNA enzymes were initially organized in multienzyme complexes featuring (1) the continuous attachment of substrates to CoA-like carriers, as in fatty acid synthesis; and (2) the ordering of RNA
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Regulation of the Mitochondrial Multienzyme Complexes in Complex Metabolic Systemsa
Annals of the New York Academy of Sciences, 1989During the past two decades, I and the members of my laboratory have enjoyed very much contributing to the body of knowledge concerning the alpha-keto acid dehydrogenase complexes. We would hope that some of our work has allowed those interested in this area a perception as to how these interesting enzyme complexes are regulated in intact metabolic ...
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[Structure-activity relationships in multienzyme complexes].
Molekuliarnaia biologiia, 1996Structures and molecular kinetic models of function of 2-oxo acid dehydrogenase complexes were analyzed. It was suggested that identical protein subunits in the multienzyme complexes as in the structure capable of self-assembly have identical contacts with the neighbors and identical environment.
B N, Gol'dshteĭn +2 more
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