Bioconjugate chemistry, 2020 Multienzyme complexes, or metabolons, are natural assemblies or clusters of sequential enzymes in biosynthesis. Spatial proximity of the enzyme active sites results in a substrate channeling effect, streamlines the cascade reaction, and increases the ...
Qixin Wei, Sicong He, J. Qu, Jiang Xia
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Biomolecules, 2021 The use of multienzyme complexes can facilitate biocatalytic cascade reactions by employing fusion enzymes or protein tags. In this study, we explored the use of recently developed peptide tags that promote complex formation of the targeted proteins: the
Ni Nyoman Purwani +3 more
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Synthetic Multienzyme Assemblies for Natural Product Biosynthesis
ChemBioChem, 2023 In nature, enzymes that catalyze sequential reactions are often assembled as clusters or complexes. The formation of multienzyme complexes, or metabolons, brings the enzyme active sites into proximity to promote intermediate transfer, decrease ...
Min Liu +4 more
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Metabolic Fuel for Epigenetic: Nuclear Production Meets Local Consumption
Frontiers in Genetics, 2021 Epigenetic modifications are responsible for finetuning gene expression profiles to the needs of cells, tissues, and organisms. To rapidly respond to environmental changes, the activity of chromatin modifiers critically depends on the concentration of a ...
Ruben Boon, Ruben Boon, Ruben Boon
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Exogenous dietary enzyme formulations improve growth performance of broiler chickens fed a low-energy diet targeting the intestinal nutrient transporter genes. [PDF]
PLoS ONE, 2018 Diminishing the cost of broiler chicken diet is a critical issue in the poultry industry. Numerous studies were performed to achieve this pivotal objective by diet supplementation with alternative feed additives.
Ahmed A Saleh +5 more
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Crystallography of a multienzyme complex containing rubisco [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 1993 M.V. Hosur, K. K. Kannan
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Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly [PDF]
, 2011 The final version of this article is available at the link below.Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies of three distinct enzymes (E1–E3) and an
Alan Cooper +44 more
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Human 2-Oxoglutarate Dehydrogenase Complex E1 Component Forms a Thiamin-derived Radical by Aerobic Oxidation of the Enamine Intermediate. [PDF]
, 2014 Herein are reported unique properties of the human 2-oxoglutarate dehydrogenase multienzyme complex (OGDHc), a rate-limiting enzyme in the Krebs (citric acid) cycle.
Ambrus, Attila +5 more
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Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells
Frontiers in Molecular Biosciences, 2020 The human translation machinery includes three types of supramolecular complexes involved in elongation of the polypeptide chain: the ribosome, complex of elongation factors eEF1B and multienzyme aminoacyl-tRNA synthetase complex.
Boris Negrutskii
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Research progress of multi-enzyme complexes based on the design of scaffold protein
Bioresources and Bioprocessing, 2023 Multi-enzyme complexes designed based on scaffold proteins are a current topic in molecular enzyme engineering. They have been gradually applied to increase the production of enzyme cascades, thereby achieving effective biosynthetic pathways.
Xiangyi Wang +5 more
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