Abstract Background Germline pathogenic variants can inform targeted therapy for metastatic prostate cancer (mPC), and improve cancer early detection and risk reduction for family members. Guidelines recommend germline genetic testing be offered to all men with mPC, yet uptake of testing is only 10%–12%. Methods This prospective study enrolled veterans
Bruce Montgomery +18 more
wiley +1 more source
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Sheep Infection Trials with 'Phase-Locked' Vpma Expression Variants of Mycoplasma agalactiae-Towards Elucidating the Role of a Multigene Family Encoding Variable Surface Lipoproteins in Infection and Disease. [PDF]
Chopra-Dewasthaly R +8 more
europepmc +1 more source
Keratinocyte‐Associated Biomarkers Reveal Pathogenic Mechanisms in Acne
The study workflow integrates scRNA‐seq and bulk RNA‐seq data to characterize acne pathogenesis. Step 1 identifies expanded keratinocyte populations using single‐cell analysis. Step 2 filters candidate genes via WGCNA and differential expression integration.
Sini Cai +5 more
wiley +1 more source
Genomic Profiling of Pediatric Solid Tumors With a Dual DNA/RNA Panel: JCCG‐TOP2 Study
In the JCCG‐TOP2 nationwide pediatric cancer genomic profiling study, 204 patients' tumors and peripheral blood from 50 institutions across Japan were successfully analyzed using a dual DNA/RNA panel. A total of 147 (72%) had potentially actionable findings, including diagnostic, prognostic, and therapeutic findings in 111 (54%), 61 (30%), and 64 (31%),
Kayoko Tao +38 more
wiley +1 more source
Abstract Advances in Macrodasyida (Gastrotricha) phylogenetics, fuelled by new species discoveries and molecular data, are reshaping taxonomic classifications. Molecular analyses suggest polyphyly in Cephalodasyidae and Macrodasyidae, yet insufficient sampling continues to obscure precise relationships.
Agata Cesaretti +3 more
wiley +1 more source
Evaluation of the Integration of Genetics and Genomics Into Nursing Practice
ABSTRACT Purpose Assess US registered nurse genomic competency. Design Administered the Genetics and Genomics Nursing Practice Survey (GGNPS). Methods GGNPS assesses genomic knowledge, skills, attitudes, confidence, and utilization in nursing practice. Distributed by the American Nurses Association via email and online to US registered nurses.
Kathleen Calzone +5 more
wiley +1 more source
Editorial: Invertebrate UDP-Glycosyltransferases: Nomenclature, Diversity and Functions
Seung-Joon Ahn +4 more
doaj +1 more source
The soybean (Glycine max L.) cytokinin oxidase/dehydrogenase multigene family; Identification of natural variations for altered cytokinin content and seed yield. [PDF]
Nguyen HN +4 more
europepmc +1 more source
Developmental regulation of expression of the lactate dehydrogenase (LDH) multigene family during mouse spermatogenesis [PDF]
Expression of the Lactate Dehydrogenase (LDH) genes during various stages of spermatogenesis was studied by using a combination of Northern blot analyses and in situ hybridization techniques.
Bellvé, Anthony +6 more
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