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The number of alleles in multigene families
Theoretical Population Biology, 1990The probability distribution and moments of the number of alleles present in a sample of homologous chromosomes are studied. It is assumed that there are multiple copies of the gene on each chromosome. When there are only two copies per chromosome or when there are only two or three chromosomes, it is possible to use analytic methods to tackle the ...
Griffiths, R. C., Watterson, G. A.
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The olfactory multigene family
Current Opinion in Genetics & Development, 1992A novel multigene family has been identified that is likely to encode odorant receptors on olfactory sensory neurons. Further studies on this gene family are likely to shed light on the molecular mechanisms underlying information coding in the mammalian olfactory system. This review is also published in Current Opinion in Neurobiology 1992, 2:282-288.
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Rat Metallothionein Multigene Family
1987Southern blot analysis of rat genomic DNA reveals the presence of numerous sequences homologous to the rat MT-1 gene. We have isolated and characterized by sequence analysis the rat MT-1 gene and three related processed pseudogenes. We discuss mechanisms by which these pseudogenes were formed.
R D, Andersen +4 more
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Genetic variation in multigene families
Nature, 1977THE possibility that some important quantitative characters of higher organisms may be subject to multigene families such as that of immunoglobulin variable parts1, poses the problem of reformulation on some of the population genetics theory. The two remarkable characteristics of multigene families as shown by Hood and others1–3—the contraction and ...
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Two chromosomes with multigene families
Theoretical Population Biology, 1991Watterson's formulae for the distribution, mean, and variance of the number of alleles in common on two chromosomes with multigene families are derived as simpler forms, and extended to chromosomes with an infinite number of genes, each evolving as in an infinitely many alleles model.
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Malaria Multigene Families: The Price of Chronicity
Parasitology Today, 2000In this article, Georges Snounou, William Jarra and Peter Preiser discuss the survival strategy of malaria parasites in the light of a novel mechanism of clonal phenotypic variation recently described for a multigene family of Plasmodium yoelii yoelii.
G, Snounou, W, Jarra, P R, Preiser
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Evolution of the Trappin Multigene Family in the Suidae
Journal of Biochemistry, 1998Trappins are a group of secretory proteins containing a WAP motif with an anchoring domain. Previous studies showed that their genes, especially those of pig, have undergone rapid evolution, which produced trappins with a broad spectrum of actions. To understand the evolution of such a rapidly evolving multigene family, we isolated trappin genes of the
Furutani, Y. +5 more
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Multigene families and the evolution of complexity
Journal of Molecular Evolution, 1991Higher organisms are complex, and their developmental processes are controlled by the sequential expression of genes that often form multigene families. Facts are surveyed on how functional diversity of genes is related to duplication of genes or segments of genes, by emphasizing that diversity is often enhanced by alternate splicing and proteolytic ...
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The Actin and Myosin Multigene Families
1985The Actin and Myosin Multigene Families: a) a study of the accumulation of their RNA transcripts demonstrates different developmental strategies during skeletal muscle formation, b) a genetic analysis of their chromosomal organization indicates gene dispersion and permits some precise localizations on the genetic map of the mouse.
M, Buckingham +8 more
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The plant multigenic family of thiol peroxidases
Free Radical Biology and Medicine, 2005Thiol peroxidases are ubiquitous recently characterized heme-free peroxidases, which catalyze the reduction of peroxynitrites and of various peroxides by catalytic cysteine residues and thiol-containing proteins as reductants. In plants, five different classes can be distinguished, according to the number and the position of conserved catalytic ...
Rouhier, Nicolas, Jacquot, J.P.
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