Results 41 to 50 of about 448,339 (311)

In situ and in vitro cryo-EM reveal structures of mycobacterial encapsulin assembly intermediates

Communications Biology
Prokaryotes rely on proteinaceous compartments such as encapsulin to isolate harmful reactions. Encapsulin are widely expressed by bacteria, including the Mycobacteriaceae, which include the human pathogens Mycobacterium tuberculosis and Mycobacterium ...
Casper Berger, Chris Lewis, Ye Gao, Kèvin Knoops, Carmen López-Iglesias, Peter J. Peters, Raimond B. G. Ravelli   +6 more
doaj   +1 more source

Integrative prediction of gene expression with chromatin accessibility and conformation data

Epigenetics & Chromatin, 2020
Background Enhancers play a fundamental role in orchestrating cell state and development. Although several methods have been developed to identify enhancers, linking them to their target genes is still an open problem. Several theories have been proposed
Florian Schmidt, Fabian Kern, Marcel H. Schulz   +2 more
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Original Research. Transluminal Contrast Attenuation Gradient Is Associated with Coronary Plaque Vulnerability — a Computed Tomography Angiography-based Study

Journal of Cardiovascular Emergencies, 2017
The aim of this study was to demonstrate that the transluminal contrast attenuation gradient (TAG), a new CT imaging-derived marker of functional significance of a coronary stenosis, is directly associated with the vulnerability degree of atheromatous ...
Orzan Marius, Hodas Roxana, Dobra Mihaela, Rat Nora, Chitu Monica, Benedek Imre   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Polishing dental ceramics using shear-thickening slurry

Scientific Reports
Nowadays, there is a great demand for Zirconia dental ceramics, while the existing low-cost automated polishing methods are quite limited. We propose a novel polishing methodology employing the shear-thickening slurry (STF) comprising starch and SiC ...
Zhenfeng Zhou, Lijun Zhu, Jiayu Wang, Xiaoxing Dong   +3 more
doaj   +1 more source

High-Precision 3D Reconstruction Study with Emphasis on Refractive Calibration of GelStereo-Type Sensors

Sensors, 2023
GelStereo sensing technology is capable of performing three-dimensional (3D) contact shape measurement under various contact structures such as bionic curved surfaces, which has promising advantages in the field of visuotactile sensing.
Chaofan Zhang, Shaowei Cui, Shuo Wang, Jingyi Hu, Yipeng Huangfu, Boyue Zhang   +5 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Multimodal Trivariate Thematic Maps with Auditory and Haptic Display [PDF]

, 2005
The purpose of this study is to explore the possibility of multimodal trivariate thematic maps by utilizing auditory and haptic displays. With two different modes of display (color only displays and multimodal displays with color, audio, and haptic), the
Jeong, Wooseob
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