Results 81 to 90 of about 1,322,987 (378)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Multimodal precision MRI of the individual human brain at ultra-high fields

Scientific Data
Multimodal neuroimaging, in particular magnetic resonance imaging (MRI), allows for non-invasive examination of human brain structure and function across multiple scales.
Donna Gift Cabalo, Ilana Ruth Leppert, Risavarshni Thevakumaran, Jordan DeKraker, Youngeun Hwang, Jessica Royer, Valeria Kebets, Shahin Tavakol, Yezhou Wang, Yigu Zhou, Oualid Benkarim, Nicole Eichert, Casey Paquola, Julien Doyon, Christine Lucas Tardif, David Rudko, Jonathan Smallwood, Raul Rodriguez-Cruces, Boris C. Bernhardt   +18 more
doaj   +1 more source

High-Precision 3D Reconstruction Study with Emphasis on Refractive Calibration of GelStereo-Type Sensors

Sensors, 2023
GelStereo sensing technology is capable of performing three-dimensional (3D) contact shape measurement under various contact structures such as bionic curved surfaces, which has promising advantages in the field of visuotactile sensing.
Chaofan Zhang, Shaowei Cui, Shuo Wang, Jingyi Hu, Yipeng Huangfu, Boyue Zhang   +5 more
doaj   +1 more source

Anestesia multimodal intratecal en cesáreas, cambios que mejoran su eficacia y seguridad: ensayo clínico [PDF]

, 2023
Raúl Antonio de Alba-Valverde, Carla Lizeth Aguilar-González, María de Lourdes Moreno-Barrón   +2 more
openalex   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Polishing dental ceramics using shear-thickening slurry

Scientific Reports
Nowadays, there is a great demand for Zirconia dental ceramics, while the existing low-cost automated polishing methods are quite limited. We propose a novel polishing methodology employing the shear-thickening slurry (STF) comprising starch and SiC ...
Zhenfeng Zhou, Lijun Zhu, Jiayu Wang, Xiaoxing Dong   +3 more
doaj   +1 more source

A multi-source behavioral and physiological recording system for cognitive assessment

Scientific Reports, 2023
Cognitive assessment has a broad application prospect, including estimate of childhood neuro development and maturation, diagnosis of neurodegenerative diseases, and selection for special profession.
Zi-yang Wang, Li Liu, Yu Liu
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Using Visual Journals as a Reflective Worldview Window into Educator Identity

, 2020
This ethnographic case study research and content analysis presents the conclusion of a three-year study involving 37 teacher candidate participants across a three-year study within a two year (2 semester program) Bachelor of Education program at a ...
Belcher, Christina, Loerts, Terry
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