Results 61 to 70 of about 2,125,197 (256)

Causal association of cognitive reserve on Alzheimer's disease with putative sex difference

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction Sex‐dependent risk factors may underlie sex differences in Alzheimer's disease (AD). Methods Using sex‐stratified genome‐wide association studies (GWAS) of AD, we evaluated associations of 12 traits with AD through polygenic risk scores (PRS)
Hao Wang, Brin Sara Rosenthal, Carolina Makowski, Min‐Tzu Lo, Ole A. Andreassen, Rany M. Salem, Linda K. McEvoy, Mark Fiecas, Chi‐Hua Chen   +8 more
doaj   +1 more source

The Skin Epilipidome in Stress, Aging, and Inflammation

Frontiers in Endocrinology, 2021
Lipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface ...
Florian Gruber, Florian Gruber, Florian Gruber, Martina Marchetti-Deschmann, Martina Marchetti-Deschmann, Christopher Kremslehner, Christopher Kremslehner, Christopher Kremslehner, Markus Schosserer, Markus Schosserer, Markus Schosserer   +10 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Atypical functional connectome hierarchy in autism

Nature Communications, 2019
Autism spectrum disorder (ASD) is associated with symptoms ranging from sensory hypersensitivity to social difficulties. Here, the authors provide evidence of atypical connectivity transitions between sensory and higher-order cortical areas in people ...
Seok-Jun Hong, Reinder Vos de Wael, Richard A. I. Bethlehem, Sara Lariviere, Casey Paquola, Sofie L. Valk, Michael P. Milham, Adriana Di Martino, Daniel S. Margulies, Jonathan Smallwood, Boris C. Bernhardt   +10 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Multimodal Imaging of Punctate Outer Retinal Toxoplasmosis

, 2019
To describe the multimodal imaging characteristics associated with punctate outer retinal toxoplasmosis (PORT).info:eu-repo/semantics ...
Freund, K Bailey, Freund, Bailey KB, Orly Gal-Or, Gregori, Giovanni, Motulsky, Elie, Rosenfeld, Philip J, Swaminathan, Swarup S, Yale Fisher, Emmett T. Cunningham, Philip J. Rosenfeld, Nicolas A. Yannuzzi, Cunningham, Emmett T., Davis, Janet L, Elie Motulsky, Fisher, Yale, Swarup S. Swaminathan, Gal-Or, Orly, Giovanni Gregori, Yannuzzi, Nicolas NA, Janet L. Davis, Yannuzzi, Nicolas A, Cunningham, Jr, Emmett T, K. Bailey Freund   +22 more
core   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

Scientific Reports, 2018
Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaque’s morphology and its biochemical composition affect the level
Min Woo Lee, Joon Woo Song, Woo Jae Kang, Hyeong Soo Nam, Tae Shik Kim, Sunwon Kim, Wang-Yuhl Oh, Jin Won Kim, Hongki Yoo   +8 more
doaj   +1 more source