Results 41 to 50 of about 157,902 (299)

Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex

Nature Communications, 2022
Brain structure scaffolds intrinsic function, supporting cognition and behavioral flexibility. Here, the authors show how macroscale organization of cortical microstructure and resting-state function uncouple in transmodal cortex of humans and macaques.
Sofie L. Valk, Ting Xu, Casey Paquola, Bo-yong Park, Richard A. I. Bethlehem, Reinder Vos de Wael, Jessica Royer, Shahrzad Kharabian Masouleh, Şeyma Bayrak, Peter Kochunov, B. T. Thomas Yeo, Daniel Margulies, Jonathan Smallwood, Simon B. Eickhoff, Boris C. Bernhardt   +14 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

One section, two worlds: single-cell integration of MALDI-MSI and spatial transcriptomics on the same single tissue section

Scientific Reports
Understanding tissue complexity requires spatially resolved multi-omics data at single-cell resolution. Here, we present a workflow integrating high-resolution matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) with Xenium ...
Tim F. E. Hendriks, Gert B. Eijkel, Theodoros Visvikis, Benjamin Balluff, Ron M. A. Heeren, Eva Cuypers   +5 more
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

A Comparative Preliminary Study on CT Contrast Attenuation Gradient Versus Invasive FFR in Patients with Unstable Angina

Journal of Cardiovascular Emergencies, 2017
The aim of this preliminary study was to assess the effectiveness of transluminal contrast attenuation gradient (TAG) determined by computed tomographic angiography (CTA), for the evaluation of the functional significance of coronary artery stenoses in ...
Orzan Marius, Dobra Mihaela, Chițu Monica   +2 more
doaj   +1 more source

The Skin Epilipidome in Stress, Aging, and Inflammation

Frontiers in Endocrinology, 2021
Lipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface ...
Florian Gruber, Florian Gruber, Florian Gruber, Martina Marchetti-Deschmann, Martina Marchetti-Deschmann, Christopher Kremslehner, Christopher Kremslehner, Christopher Kremslehner, Markus Schosserer, Markus Schosserer, Markus Schosserer   +10 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study

Schizophrenia
Impaired insight into illness occurs in up to 98% of patients with schizophrenia, depending on the stage of illness, and leads to negative clinical outcomes.
Jianmeng Song, Edgardo Carmona-Torres, Yasaman Kambari, Sofia Chavez, Fumihiko Ueno, Teruki Koizum, Aron Amaev, Ali Abdolizadeh, Vincenzo De Luca, Daniel M. Blumberger, Gary Remington, Bruce Pollock, Ariel Graff-Guerrero, Philip Gerretsen   +13 more
doaj   +1 more source

Convergence of cortical types and functional motifs in the human mesiotemporal lobe

eLife, 2020
The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex ...
Casey Paquola, Oualid Benkarim, Jordan DeKraker, Sara Larivière, Stefan Frässle, Jessica Royer, Shahin Tavakol, Sofie Valk, Andrea Bernasconi, Neda Bernasconi, Ali Khan, Alan C Evans, Adeel Razi, Jonathan Smallwood, Boris C Bernhardt   +14 more
doaj   +1 more source

Causal association of cognitive reserve on Alzheimer's disease with putative sex difference

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction Sex‐dependent risk factors may underlie sex differences in Alzheimer's disease (AD). Methods Using sex‐stratified genome‐wide association studies (GWAS) of AD, we evaluated associations of 12 traits with AD through polygenic risk scores (PRS)
Hao Wang, Brin Sara Rosenthal, Carolina Makowski, Min‐Tzu Lo, Ole A. Andreassen, Rany M. Salem, Linda K. McEvoy, Mark Fiecas, Chi‐Hua Chen   +8 more
doaj   +1 more source