Results 51 to 60 of about 2,125,197 (256)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Strategies for collection, management, and release of data for multi-site longitudinal studies: Lessons from the ABCD Data Analysis, Informatics, & Resource Center

Developmental Cognitive Neuroscience
This paper synthesizes ten years of experience from the Adolescent Brain Cognitive DevelopmentSM (ABCD) Study’s Data Analysis, Informatics, & Resource Center (DAIRC), focusing on strategies for the collection, management, and release of data for a ...
Janosch Linkersdörfer, Sammy Berman, Calen Smith, Laura Ziemer, Le Zhang, Shermaine Abad, Joseph Baligh, Tyler Berkness, Erika Bolden, Alexander DeCastro, Olivier Celhay, Biplabendu Das, Gayathri Dowling, Kimberly Garcia, Luis Garduno, Donald J. Hagler, Jr., Elizabeth A. Hoffman, Jana Hong, Adam Kehl, Josh Kuperman, Kimberly LeBlanc, Robert Loughnan, Matthew Nguyen, Pravesh Parekh, Diliana Pecheva, Sejal Shanbhag, Wesley K. Thompson, Brandon Tsui, Rongguang Yang, Anders M. Dale   +29 more
doaj   +1 more source

Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex

Nature Communications, 2022
Brain structure scaffolds intrinsic function, supporting cognition and behavioral flexibility. Here, the authors show how macroscale organization of cortical microstructure and resting-state function uncouple in transmodal cortex of humans and macaques.
Sofie L. Valk, Ting Xu, Casey Paquola, Bo-yong Park, Richard A. I. Bethlehem, Reinder Vos de Wael, Jessica Royer, Shahrzad Kharabian Masouleh, Şeyma Bayrak, Peter Kochunov, B. T. Thomas Yeo, Daniel Margulies, Jonathan Smallwood, Simon B. Eickhoff, Boris C. Bernhardt   +14 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Contracted functional connectivity profiles in autism

Molecular Autism
Objective Autism spectrum disorder (ASD) is a neurodevelopmental condition that is associated with atypical brain network organization, with prior work suggesting differential connectivity alterations with respect to functional connection length.
Clara F. Weber, Valeria Kebets, Oualid Benkarim, Sara Lariviere, Yezhou Wang, Alexander Ngo, Hongxiu Jiang, Xiaoqian Chai, Bo-yong Park, Michael P. Milham, Adriana Di Martino, Sofie Valk, Seok-Jun Hong, Boris C. Bernhardt   +13 more
doaj   +1 more source

Novel Multimodal, Multiscale Imaging System with Augmented Reality

, 2021
A novel multimodal, multiscale imaging system with augmented reality capability were developed and characterized. The system offers 3D color reflectance imaging, 3D fluorescence imaging, and augmented reality in real time. Multiscale fluorescence imaging
Yang Liu, Christopher Mela, Francis Papay   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Comparative Preliminary Study on CT Contrast Attenuation Gradient Versus Invasive FFR in Patients with Unstable Angina

Journal of Cardiovascular Emergencies, 2017
The aim of this preliminary study was to assess the effectiveness of transluminal contrast attenuation gradient (TAG) determined by computed tomographic angiography (CTA), for the evaluation of the functional significance of coronary artery stenoses in ...
Orzan Marius, Dobra Mihaela, Chițu Monica   +2 more
doaj   +1 more source

Convergence of cortical types and functional motifs in the human mesiotemporal lobe

eLife, 2020
The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex ...
Casey Paquola, Oualid Benkarim, Jordan DeKraker, Sara Larivière, Stefan Frässle, Jessica Royer, Shahin Tavakol, Sofie Valk, Andrea Bernasconi, Neda Bernasconi, Ali Khan, Alan C Evans, Adeel Razi, Jonathan Smallwood, Boris C Bernhardt   +14 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source