Convergence of cortical types and functional motifs in the human mesiotemporal lobe
eLife, 2020 The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex ...
Casey Paquola +14 more
doaj +1 more source
Causal association of cognitive reserve on Alzheimer's disease with putative sex difference
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021 Introduction Sex‐dependent risk factors may underlie sex differences in Alzheimer's disease (AD). Methods Using sex‐stratified genome‐wide association studies (GWAS) of AD, we evaluated associations of 12 traits with AD through polygenic risk scores (PRS)
Hao Wang +8 more
doaj +1 more source
Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel +5 more
wiley +1 more source
Contracted functional connectivity profiles in autism
Molecular AutismObjective Autism spectrum disorder (ASD) is a neurodevelopmental condition that is associated with atypical brain network organization, with prior work suggesting differential connectivity alterations with respect to functional connection length.
Clara F. Weber +13 more
doaj +1 more source
Similar Genetic Architecture of Alzheimer’s Disease and Differential APOE Effect Between Sexes
Frontiers in Aging Neuroscience, 2021 Sex differences have been observed in the clinical manifestations of Alzheimer’s disease (AD) and elucidating their genetic basis is an active research topic.
Hao Wang +9 more
doaj +1 more source
Multimodal Representation Learning With Text and Images [PDF]
, 2022 Aishwarya Jayagopal +3 more
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source
BIO-CXRNET: A Robust Multimodal Stacking Machine Learning Technique for Mortality Risk Prediction of COVID-19 Patients using Chest X-Ray Images and Clinical Data [PDF]
, 2022 Tawsifur Rahman +12 more
openalex +1 more source
Multimodal imaging of thyroid cancer
Current Opinion in Endocrinology, Diabetes & Obesity, 2020 Purpose of review Thyroid cancer is the most common endocrine cancer in adults with rising incidence. Challenges in imaging thyroid cancer are twofold: distinguishing thyroid cancer from benign thyroid nodules, which occur in 50% of the population over ...
K. Brauckhoff, M. Biermann
semanticscholar +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source