Results 31 to 40 of about 47,222 (292)

Multimorbidity and Evidence Generation [PDF]

Journal of General Internal Medicine, 2014
Most people with a chronic disease actually have more than one, a condition known as multimorbidity. Despite this, the evidence base to prevent adverse disease outcomes has taken a disease-specific approach. Drawing on a conference, Improving Guidelines for Multimorbid Patients, the goal of this paper is to identify challenges to the generation of ...
Weiss, Carlos O, Varadhan, Ravi, Puhan, Milo A, Vickers, Andrew, Bandeen-Roche, Karen, Boyd, Cynthia M, Kent, David M   +6 more
openaire   +2 more sources

Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of α_IIbβ₃ and Modulation of Fibrinogen

Biomolecules
In the vascular system, pathological conditions that cause hypoxia are associated with increased platelet activity and thrombosis. Using a platelet spreading assay, we show that severe hypoxia (i.e., 1%), venous (i.e., 5%), and, surprisingly, arterial (i.
Sophie V. L. Leonard, Zoe Booth, Leigh Naylor-Adamson, Lewis Bibby, Katie S. Wraith, Giordano Pula, Monica Arman, Simon D. J. Calaminus   +7 more
doaj   +1 more source

Regional variation in multimorbidity prevalence in British Columbia, Canada: a cross-sectional analysis of Canadian Community Health Survey data, 2015/16

Health Promotion and Chronic Disease Prevention in Canada, 2020
Introduction: Multimorbidity represents a major concern for population health and service delivery planners. Information about the population prevalence (absolute numbers and proportions) of multimorbidity among regional health service delivery ...
C. Andrew Basham
doaj   +1 more source

Association Between Symptomatic Knee Osteoarthritis and Target Glycemic Control in Individuals with Type 2 Diabetes

Arthritis Care &Research, Accepted Article.
Objective Knee osteoarthritis (OA) commonly affects individuals with Type 2 diabetes (T2DM) and is associated with increased risk of diabetes‐related complications. To better understand potential mechanisms, we examined the association between symptomatic knee OA and glycemic control in individuals with T2DM.
Lauren K. King, Alanna Weisman, Baiju R. Shah, Robert Goldberg, Amish Parikh, Ian Stanaitis, Vivian Hung, Rosane Nisenbaum, Abdalmohsen Almodahka, Lorraine Lipscombe, Gillian A. Hawker   +10 more
wiley   +1 more source

OBUSight: Clinically Aligned Generative AI for Ophthalmic Ultrasound Interpretation and Diagnosis

Advanced Science, EarlyView.
OBUSight, a clinically aligned generative AI model that jointly generates reports and predicts diseases through multimodal semantic alignment, was trained and validated on a large multicenter dataset. OBUSight outperformed eight state‐of‐the‐art models, provided clinically reliable reports, enhanced diagnostic efficiency, and achieved performance ...
Xiaocong Liu, An Shao, Bingtao Guan, Ziyao Luo, Weiyi Lai, Xiaoling Huang, Jun Liu, Jie Yan, Huimin Li, Xiangji Pan, Jiawei Wang, Zichang Su, Yih Chung Tham, Jie Yang, Haotian Lin, Juan Ye, Hongxia Xu, Jian Wu   +17 more
wiley   +1 more source

Targeting DNA Damage Response-Mediated Resistance in Non-Small Cell Lung Cancer: From Mechanistic Insights to Drug Development

Current Oncology
Non-small cell lung cancer (NSCLC) remains a major contributor to cancer-related deaths worldwide, with therapeutic resistance presenting a critical clinical hurdle.
Xue Gong, Yongzhao Zhou, Yi Deng
doaj   +1 more source

Measuring multimorbidity in hospitalised patients using linked hospital episode data: comparison of two measures

International Journal of Population Data Science, 2019
Introduction Multimorbidity is a complex and growing health challenge. There is no accepted “gold standard” multimorbidity measure for hospital resource planning, and few studies have compared measures in hospitalised patients.
Lynn Robertson, Dolapo Ayansina, Marjorie Johnston, Angharad Marks, Corri Black   +4 more
doaj   +1 more source

Effect of multimorbidity on hypertension management

Scientific Reports, 2023
Multimorbidity, the coexistence of multiple health conditions, is associated with functional decline, disability, and mortality. We aimed to investigate the effects of multimorbidity on hypertension treatment and control rates by analyzing data from the ...
Eunjeong Ji, Soyeon Ahn, Jung-Yeon Choi, Cheol-Ho Kim, Kwang-il Kim   +4 more
doaj   +1 more source

SLPI⁺ AT2‐Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche

Advanced Science, EarlyView.
Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang, Guonian Zhu, Pan Tang, Yan Wang, Wenxin Luo, Wenpeng Song, Zhikang Pan, Bingjie Zheng, YongChao Jiang, Defu Xiao, Xin Jin, Yong Bai, Guowei Che, Weimin Li   +13 more
wiley   +1 more source

Temporal change in multimorbidity prevalence, clustering patterns, and the association with mortality: findings from the China Kadoorie Biobank study in Jiangsu Province

Frontiers in Public Health
ObjectivesThe characteristics of multimorbidity in the Chinese population are currently unclear. We aimed to determine the temporal change in multimorbidity prevalence, clustering patterns, and the association of multimorbidity with mortality from all ...
Hao Yu, Hao Yu, Ran Tao, Jinyi Zhou, Jian Su, Yan Lu, Yujie Hua, Jianrong Jin, Pei Pei, Canqing Yu, Canqing Yu, Canqing Yu, Dianjianyi Sun, Dianjianyi Sun, Dianjianyi Sun, Zhengming Chen, Liming Li, Liming Li, Liming Li, Jun Lv, Jun Lv, Jun Lv   +21 more
doaj   +1 more source