Results 51 to 60 of about 85,807 (301)

Measuring multimorbidity in hospitalised patients using linked hospital episode data: comparison of two measures

International Journal of Population Data Science, 2019
Introduction Multimorbidity is a complex and growing health challenge. There is no accepted “gold standard” multimorbidity measure for hospital resource planning, and few studies have compared measures in hospitalised patients.
Lynn Robertson, Dolapo Ayansina, Marjorie Johnston, Angharad Marks, Corri Black   +4 more
doaj   +1 more source

The burden of disease-specific multimorbidity among older adults in India and its states: evidence from LASI

BMC Geriatrics, 2023
Background Around the world, advances in public health and changes in clinical interventions have resulted in increased life expectancy. Multimorbidity is becoming more of an issue, particularly in countries where the population is rapidly ageing.
Priyanka Patel, T. Muhammad, Harihar Sahoo   +2 more
doaj   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Prone positioning does not improve outcomes of intubated patients with pneumocystis pneumonia and moderate–severe acute respiratory distress syndrome: a single-center, retrospective, observational, cohort study

European Journal of Medical Research
Background Pneumocystis pneumonia is an uncommon precipitant of acute respiratory distress syndrome and is associated with high mortality. Prone positioning ventilation has been proven to reduce mortality in patients with moderate–severe acute ...
Zhen Wang, Yuyan Zhou, Min Zhu, Faping Wang, Yubei Zhou, He Yu, Fengming Luo   +6 more
doaj   +1 more source

Alzheimer’s Disease–Thrombosis Comorbidity: A Growing Body of Evidence from Patients and Animal Models

Cells
Background/Objectives: A growing body of evidence is amassing in the literature suggesting a correlation between Alzheimer’s disease (AD) and thrombotic vascular complications, which led to the suggestive hypothesis that thrombosis may contribute to AD ...
Joanna Koch-Paszkowski, Christopher Sennett, Giordano Pula   +2 more
doaj   +1 more source

The relationship of individual comorbid chronic conditions to diabetes care quality. [PDF]

, 2015
ObjectiveMultimorbidity affects 26 million persons with diabetes, and care for comorbid chronic conditions may impact diabetes care quality. The aim of this study was to determine which chronic conditions were related to lack of achievement or ...
Bolt, Daniel M, Fink, Jennifer, Greenlee, Robert T, Magnan, Elizabeth M, Mahoney, Jane E, Palta, Mari, Pandhi, Nancy, Smith, Maureen A   +7 more
core   +2 more sources

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Association between multimorbidity patterns and disability among older people covered by long-term care insurance in Shanghai, China

BMC Public Health, 2021
Background Functional disability and multimorbidity are common among older people. However, little is known about the relationship between functional disability and different multimorbidity combinations.
Zijing Wang, Wenjia Peng, Mengying Li, Xinghui Li, Tingting Yang, Cancan Li, Huosheng Yan, Xianjie Jia, Zhi Hu, Ying Wang   +9 more
doaj   +1 more source

Reply to the Comments on “GLM7—A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity”

Advanced Science, EarlyView.
ABSTRACT This paper is a formal response to the comments raised by Yiquan Wang et al. and Peikai Sun et al. on our published work entitled “GLM7–A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity”. We address all the comments in this response.
Zhihua Wang, Suowen Xu
wiley   +1 more source

Socioeconomic context, individual characteristics, and multimorbidity among older adults: a nationwide cross-sectional study [PDF]

Geriatrics, Gerontology and Aging
Objectives: The study investigated the prevalence of multimorbidity among older adults and its association with socioeconomic context and individual characteristics.
João Vitor Rodrigues, Simone Farías-Antúnez, Claúdia Weber Corseuil, Maruí Weber Corseuil Giehl   +3 more
doaj   +1 more source