Results 61 to 70 of about 56,158 (307)

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Increasing clinical, community, and patient-centered health research [PDF]

, 2013
The report “Multiple Chronic Conditions: A Strategic Framework,” which was developed by the U.S. Department of Health & Human Services (HSS), has identified as one of the key goals for improving health and the provision of healthcare for people with ...
Jose M. Valderas, Valderas, Jose M.
core   +2 more sources

Temporal change in multimorbidity prevalence, clustering patterns, and the association with mortality: findings from the China Kadoorie Biobank study in Jiangsu Province

Frontiers in Public Health
ObjectivesThe characteristics of multimorbidity in the Chinese population are currently unclear. We aimed to determine the temporal change in multimorbidity prevalence, clustering patterns, and the association of multimorbidity with mortality from all ...
Hao Yu, Hao Yu, Ran Tao, Jinyi Zhou, Jian Su, Yan Lu, Yujie Hua, Jianrong Jin, Pei Pei, Canqing Yu, Canqing Yu, Canqing Yu, Dianjianyi Sun, Dianjianyi Sun, Dianjianyi Sun, Zhengming Chen, Liming Li, Liming Li, Liming Li, Jun Lv, Jun Lv, Jun Lv   +21 more
doaj   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Socioeconomic context, individual characteristics, and multimorbidity among older adults: a nationwide cross-sectional study [PDF]

Geriatrics, Gerontology and Aging
Objectives: The study investigated the prevalence of multimorbidity among older adults and its association with socioeconomic context and individual characteristics.
João Vitor Rodrigues, Simone Farías-Antúnez, Claúdia Weber Corseuil, Maruí Weber Corseuil Giehl   +3 more
doaj   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Prone positioning does not improve outcomes of intubated patients with pneumocystis pneumonia and moderate–severe acute respiratory distress syndrome: a single-center, retrospective, observational, cohort study

European Journal of Medical Research
Background Pneumocystis pneumonia is an uncommon precipitant of acute respiratory distress syndrome and is associated with high mortality. Prone positioning ventilation has been proven to reduce mortality in patients with moderate–severe acute ...
Zhen Wang, Yuyan Zhou, Min Zhu, Faping Wang, Yubei Zhou, He Yu, Fengming Luo   +6 more
doaj   +1 more source

Combined Use of Gefitinib and Bevacizumab in Advanced Non-Small-Cell Lung Cancer with EGFR G719S/S768I Mutations and Acquired C797S Without T790M After Osimertinib: A Case Report and Literature Review

Current Oncology
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective in non-small-cell lung cancer (NSCLC) with sensitizing mutations.
Wenting Lu, Jiayi Sun, Yawan Jing, Jing Xu, Chengming Huang, Yi Deng, Panwen Tian, Yalun Li   +7 more
doaj   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Chronic diseases and multi-morbidity - a conceptual modification to the WHO ICCC model for countries in health transition [PDF]

, 2014
BackgroundThe burden of non-communicable diseases is rising, particularly in low and middle-income countries undergoing rapid epidemiological transition.
Levitt, N.S., Nuala McGrath, Oni, T., McGrath, N., Rhonda BeLue, Tolu Oni, Naomi S Levitt, Oni, Tolu, Colagiuri, Stephen, May, C.R., May, Carl R, Roderick, P., Carl R May, Roderick, Paul, BeLue, R., BeLue, Rhonda, Stephen Colagiuri, Levitt, Naomi S, Colagiuri, S., McGrath, Nuala, Paul Roderick   +20 more
core   +1 more source