Results 71 to 80 of about 85,807 (301)

The science of clinical practice: disease diagnosis or patient prognosis? Evidence about "what is likely to happen" should shape clinical practice. [PDF]

, 2015
BACKGROUND: Diagnosis is the traditional basis for decision-making in clinical practice. Evidence is often lacking about future benefits and harms of these decisions for patients diagnosed with and without disease.
A Chauffard, A Vickers, AD Hingorani, Adam Timmis, AJ Vickers, Alastair D Hay, C Mar Del, CK Lee, DA Asch, Danielle A Van Der Windt, DE Newby, Douglas G Altman, E Rosenberg Charles, E Stolper, EAM Gale, EW Steyerberg, G-J Dinant, George Peat, H Downing, H Hemingway, Harry Hemingway, HG Welch, HM Krumholz, I Roberts, Ian Roberts, Independent UK Panel on Breast Cancer Screening, J Vestbo, J Wellwood, JC Hill, JG Jarvik, Jonathan J Deeks, Jutel Annemarie Goldstein, Kate M Dunn, L Ferrante di Ruffano, Linda LeResche, M Korff Von, M Roland, Michael Sharpe, Michael Von Korff, O Bruder, P Brown, Pablo Perel, PD White, Peter Croft, PM Bossuyt, R Aronowitz, R Moynihan, R Smith-Bindman, RA Aronowitz, Richard D Riley, Richard J Stevens, RK Simmons, RO Bonow, SJ Lord, SS Watson, Steffen E Petersen, TB Murdoch, WJ Katon   +57 more
core   +4 more sources

Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection

Animal Models and Experimental Medicine, EarlyView.
This study compared monkeypox virus (MPXV) infection in three small animal models: Syrian hamsters, C57BL/6 mice, and BALB/c mice. Following intraperitoneal inoculation, Syrian hamsters exhibited the highest susceptibility, with rapid systemic viral dissemination, elevated splenic and renal viral burdens, and severe histopathological damage, followed ...
Xiaohui Wei, Jing Wu, Hekai Yang, Na Li, Binbin Zhao, Wanjun Peng, Na Rong, Wei Zhang, Jing Xue, Jiangning Liu   +9 more
wiley   +1 more source

Interventions by healthcare professionals to improve management of physical long-term conditions in adults who are homeless: a systematic review protocol [PDF]

, 2017
Introduction People experiencing homelessness are at increased risk of, and have poorer outcomes from, a range of physical long-term conditions (LTCs). It is increasingly recognised that interventions targeting people who are homeless should be tailored ...
Esiovwa, Regina, Gibson, Lauren, Hanlon, Peter, Lowrie, Richard, Mair, Frances S., Williamson, Andrea E., Yeoman, Lynsey   +6 more
core   +3 more sources

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Multi-omics analyses reveal biological and clinical insights in recurrent stage I non-small cell lung cancer

Nature Communications
Post-operative recurrence rates of stage I non-small cell lung cancer (NSCLC) range from 20% to 40%. Nonetheless, the molecular mechanisms underlying recurrence hitherto remain largely elusive.
Chengdi Wang, Jingwei Li, Jingyao Chen, Zhoufeng Wang, Guonian Zhu, Lujia Song, Jiayang Wu, Changshu Li, Rong Qiu, Xuelan Chen, Li Zhang, Weimin Li   +11 more
doaj   +1 more source

Social determinants of multimorbidity and multiple functional limitations among the ageing population of England, 2002–2015

SSM: Population Health, 2019
This study explores longitudinal relationships between material, psycho-social and behavioural social determinants of health and multimorbidity of people aged 50 years or older in England.
Leo Singer, Mark Green, Francisco Rowe, Yoav Ben-Shlomo, Karyn Morrissey   +4 more
doaj   +1 more source

Are There Options to Prevent Early Occurring Deaths in Acute Myocardial Infarction: Prospective Evaluation of All < 24 h In-Hospital Deaths, 2004-2006-The MONICA/KORA Augsburg Infarction Registry [PDF]

, 2010
Objectives: To provide valid clinical data of early in-hospital deaths with presumed acute myocardial infarction (AMI) who are often not included in clinical trials or registries.
Ehmann, Anja, Greschik, Claudia, Kling, Birgitt, Kuch, Bernhard, Meisinger, Christa, Scheidt, Wolfgang von   +5 more
core   +1 more source

Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1‐mediated P53 ubiquitination

Animal Models and Experimental Medicine, EarlyView.
Based on a dermis fibroblast Gorab knockout mouse model, this study revealed that Gorab deficiency promotes skin aging by influencing RCHY1, causing a decrease in P53 ubiquitination, damaging the activity of HDAC2, further resulting in the accumulation of aging‐related proteins (P53, P21, P16) and a reduction in extracellular matrix (ECM) components ...
Yanhong Li, Wei Liang, Yanfeng Xu, Yunlin Han, Wenjie Zhao, Siyuan Wang, Wei Deng, Chuan Qin   +7 more
wiley   +1 more source

The association between multiple long‐term conditions and dementia: A UK cohort study

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Studies examining the risk of dementia in people with multimorbidity are commonly conducted in research cohorts or outside the UK. Multimorbidity has historically been associated with aging, but recent research suggests that more than half ...
Hilary Shepherd, Adam Todd, David R. Sinclair, Charlotte L. Richardson, Fiona E. Matthews, Andrew Kingston   +5 more
doaj   +1 more source

Multimorbidity [PDF]

British Dental Journal, 2021
openaire   +2 more sources