Results 31 to 40 of about 85,807 (301)

The German MultiCare-study : patterns of multimorbidity in primary health care - protocol of a prospective cohort study [PDF]

, 2009
Background Multimorbidity is a highly frequent condition in older people, but well designed longitudinal studies on the impact of multimorbidity on patients and the health care system have been remarkably scarce in numbers until today.
Ingmar Schäfer, Heike Hansen, Gerhard Schön, Wolfgang Maier, Susanne Höfels, Attila Altiner, Angela Fuchs, Ferdinand M Gerlach, Juliana J Petersen, Jochen Gensichen, Sven Schulz, Steffi Riedel-Heller, Melanie Luppa, Siegfried Weyerer, Jochen Werle, Horst Bickel, Kerstin Barth, Hans-Helmut König, Anja Rudolph, Birgitt Wiese, Jana Prokein, Monika Bullinger, Olaf von dem Knesebeck, Marion Eisele, Hanna Kaduszkiewicz, Karl Wegscheider, Hendrik van den Bussche, M Van den Akker, A Marengoni, M Fortin, R Gijsen, A Hessel, J Nuyen, MI Bisschop, CM Boyd, M Fortin, T Luck, B Terluin, JI Sheikh, JC Morris, TL Lash, F Buntinx, MD Miller, M Von Korff, S Heinrich, J Gensichen, FE Harrell, JD Singer, C Collin, MP Lawton, K Bös, K Welsh, W Van der Elst, BW Klasen, EuroQol Group, CL Craig, K Bush, A Hinz, T Fydrich, T Rosemann, L Schenk, H Brauns   +61 more
core   +1 more source

'Across the pond'—a response to the NICE guidelines for management of multi-morbidity in older people [PDF]

, 2017
No abstract ...
Stott, David J., Young, John
core   +1 more source

Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of α_IIbβ₃ and Modulation of Fibrinogen

Biomolecules
In the vascular system, pathological conditions that cause hypoxia are associated with increased platelet activity and thrombosis. Using a platelet spreading assay, we show that severe hypoxia (i.e., 1%), venous (i.e., 5%), and, surprisingly, arterial (i.
Sophie V. L. Leonard, Zoe Booth, Leigh Naylor-Adamson, Lewis Bibby, Katie S. Wraith, Giordano Pula, Monica Arman, Simon D. J. Calaminus   +7 more
doaj   +1 more source

Regional variation in multimorbidity prevalence in British Columbia, Canada: a cross-sectional analysis of Canadian Community Health Survey data, 2015/16

Health Promotion and Chronic Disease Prevention in Canada, 2020
Introduction: Multimorbidity represents a major concern for population health and service delivery planners. Information about the population prevalence (absolute numbers and proportions) of multimorbidity among regional health service delivery ...
C. Andrew Basham
doaj   +1 more source

Enhancing research quality and reporting: why the Journal of Comorbidity is now publishing study protocols [PDF]

, 2014
The Journal of Comorbidity was launched in 2011 and has since become established as a high-quality journal that publishes open-access, peer-reviewed articles, with a focus on advancing the clinical management of patients with comorbidity/multimorbidity ...
Fortin, Martin, Gunn, Jane, Mercer, Stewart W., Smith, Susan M., van den Akker, Marjan   +4 more
core   +3 more sources

Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit‐to‐stand (STS), and evaluated their abilities to predict poor health outcomes.
Kylie E. Riggles, Hannah F. Brubeck, Adrienne D. Tanus, Courtney N. Loecker, Punyasha Roul, Bryant R. England, Elizabeth R. Wahl, James S. Andrews, Namrata Singh, Joshua F. Baker, Patricia P. Katz, Dolores M. Shoback, Jose M. Garcia, Ariela R. Orkaby, Katherine D. Wysham   +14 more
wiley   +1 more source

Development and validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ) [PDF]

, 2018
OBJECTIVE: To develop and validate a new scale to assess treatment burden (the effort of looking after one's health) for patients with multimorbidity. DESIGN: Mixed-methods. SETTING: UK primary care.
Chaplin, Katherine, Duncan, Polly, Gaunt, Daisy, Man, Mei-See, Murphy, Mairead, Salisbury, Chris   +5 more
core   +3 more sources

Adverse drug reactions associated with amitriptyline - protocol for a systematic multiple-indication review and meta-analysis [PDF]

, 2020
Background: Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-thecounter products.
Brueckle, Maria-Sophie, Gerlach, Ferdinand M, Glasziou, Paul P, Gonzalez-Gonzalez, Ana Isabel, Harder, Sebastian, Muth, Christiane, Nguyen, Truc Sophia, Pilz, Maximilian, Seide, Svenja E, Thomas, Elizabeth T   +9 more
core   +1 more source

Formal and informal social care in people with Rheumatic and Musculoskeletal diseases: a cross‐sectional multicentre survey

Arthritis Care &Research, Accepted Article.
Introduction Rheumatic and musculoskeletal diseases(RMDs) are leading causes of physical disability, necessitating support with activities of daily living(ADLs). This study describes social care received by patients with RMDs in two disperate regions of England: Salford(urban) and Norfolk(rural).
Mehreen Somro, Karen Durrant, William G Dixon, John McBeth, Alex MacGregor, Max Yates, Jenny H Humphreys   +6 more
wiley   +1 more source

Targeting DNA Damage Response-Mediated Resistance in Non-Small Cell Lung Cancer: From Mechanistic Insights to Drug Development

Current Oncology
Non-small cell lung cancer (NSCLC) remains a major contributor to cancer-related deaths worldwide, with therapeutic resistance presenting a critical clinical hurdle.
Xue Gong, Yongzhao Zhou, Yi Deng
doaj   +1 more source