Results 61 to 70 of about 438,329 (261)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Broadcasting on Adversarial Multiple Access Channels [PDF]
2019 IEEE 18th International Symposium on Network Computing and Applications (NCA), 2019 We study deterministic distributed algorithms for broadcasting on multiple-access channels. Packet injection is modeled by leaky-bucket adversaries. There is a fixed set of stations attached to a channel. Additional features of the model of communication include an upper bound on the number of stations activated in a round, an individual injection rate,
Bader A. Aldawsari +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Non-Orthogonal Multiple Access Technology for 5G Systems
Dianxin kexue, 2015 To meet the 5G requirements on spectral efficiency and number of connections，non-orthogonal multiple access（NMA）technology is becoming an important candidate technology.It was shed light on how NMA can be used to further improve spectral efficiency over ...
Qi Bi, Lin Liang, Shan Yang, Peng Chen
doaj +2 more sources
Sensors, 2019 Future safety applications require the timely delivery of messages between vehicles. The 802.11p has been standardized as the standard Medium Access Control (MAC) protocol for vehicular communication.
Mohammed Abdulhakim Al-Absi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source